Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Mechanisms of Action of Probiotics

Probiotics의 작용기전

  • Ko, Jae-Sung (Department of Pediatrics, Seoul National University College of Medicine)
  • 고재성 (서울대학교 의과대학 소아과학교실)
  • Received : 2005.06.13
  • Accepted : 2005.06.16
  • Published : 2005.07.15
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Abstract

There is scientific evidence that administration of probiotics is effective in the treatment of acute infectious diarrhea in children and the prevention of antibiotic associated diarrhea and nosocomial/community acquired diarrhea. Probiotics prevent relapse of recurrent pouchitis and decrease the initial onset of pouchitis in ulcerative colitis. Probiotic organisms suppress growth of pathogens as well as their epithelial attachment and/or invasion either directly by secreting antimicrobial substances or by stimulating host expression of protective molecules. Additionally, probiotics enhance mucosal barrier function and can stimulate host production of immunosuppressive molecules that downregulate inflammatory responses or allergic immune response. Mechanisms of action explain therapeutic effects and randomized controlled trials are warranted before recommendations for therapeutic or preventive use can be given.

Keywords

References

  1. Berg RD. The indigenous gastrointestinal microflora. Trends Microbiol 1996;4:430-5 https://doi.org/10.1016/0966-842X(96)10057-3
  2. Sullivan A, Nord CE. Probiotics and gastrointestinal diseases. J Intern Med 2005;257:78-92 https://doi.org/10.1111/j.1365-2796.2004.01410.x
  3. Guandalini S, Pensabene L, Zikri MA, Dias JA, Casali LG,Hoekstra H, et al. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhoea : a multicenter European trial. J Pediatr Gastroenterol Nutr 2000;30:54-60 https://doi.org/10.1097/00005176-200001000-00018
  4. Fedorak RN, Madsen K. Probiotics and prebiotics in gastrointestinal disorders. Curr Opin Gastroenterol 2004;20:146- 55 https://doi.org/10.1097/00001574-200403000-00017
  5. Gill HS, Guarner. Probiotics and human health : a clinical perspective. Postgrad Med J 2004;80:516-26 https://doi.org/10.1136/pgmj.2003.008664
  6. Yolken RH, Ojeh C, Khatri IA, Sajjan U, Forstner JF. Intestinal mucins inhibit rotavirus replication in an oligosaccharide- dependent manner. J Infect Dis 1994;169:1002-6 https://doi.org/10.1093/infdis/169.5.1002
  7. Cadieux P, Burton J, Gardiner G, Braunstein I, Bruce AW, Kang CY, et al. Lactobacillus strains and vaginal ecology. JAMA 2002;287:1940-1 https://doi.org/10.1001/jama.287.15.1940
  8. Mack DR, Lebel S. Role of probiotics in the modulation of intestinal infections and inflammation. Curr Opin Gastroenterol 2004;20:22-6 https://doi.org/10.1097/00001574-200401000-00006
  9. Matsuzaki T, Chin J. Modulating immune responses with probiotic bacteria. Immunol Cell Biol 2000;78:67-73 https://doi.org/10.1046/j.1440-1711.2000.00887.x
  10. Miettinen M, Lehtonen A, Julkunen I, Matikainen S. Lactobacilli and streptococci activate NF-kappa B and STAT signaling pathways in human macrophages. J Immunol 2000;164:3733-40
  11. Reveneau N, Geoffroy MC, Locht C, Chagnaud P, Mercenier A. Comparison of the immune responses induced by local immunizations with recombinant Lactobacillus plantarum producing tetanus toxin fragment C in different cellular locations. Vaccine 2002;20:1769-77 https://doi.org/10.1016/S0264-410X(02)00027-0
  12. Yan F, Polk DB. Probiotic bacterium prevents cytokineinduced apoptosis in intestinal epithelial cells. J Biol Chem 2002;277:50959-65 https://doi.org/10.1074/jbc.M207050200
  13. Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases : antibiotics, probiotics, and prebiotics. Gastroenterology 2004;126:1620-33 https://doi.org/10.1053/j.gastro.2004.03.024
  14. Rachmilewitz D, Katakara K, Karmeli F, Hayashi T, Reinus C, Rudensky B, et al. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 2004;126:520-8 https://doi.org/10.1053/j.gastro.2003.11.019
  15. Sartor RB. Probiotic therapy of intestinal inflammation and infections. Curr Opin Gastroenterol 2005;21:44-50
  16. Kalliomaki, Isolauri E. Role of intestinal flora in the development of allergy. Curr Opin Allergy Clin Immunol 2003;3: 15-20 https://doi.org/10.1097/00130832-200302000-00003
  17. Bjorksten B, Naaber P, Sepp E, Mikelsaar M. The intestinal microflora in allergic Estonian and Swedish infants. Clin Exp Allergy 1999;29:342-6 https://doi.org/10.1046/j.1365-2222.1999.00560.x
  18. Rook GAW, Brunet LR. Microbes, immunoregulation, and the gut. Gut 2005;54:317-20 https://doi.org/10.1136/gut.2004.053785