The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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The Analgesic Interaction between Ketorolac and Morphine in Radiant Thermal Stimulation Rat

방사열 자극실험쥐에서 Ketorolac과 Morphine의 병용투여 효과

  • Roh, Jang Ho (Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine) ;
  • Choe, Dong Hun (Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine) ;
  • Lee, Youn Woo (Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine) ;
  • Yoon, Duck Mi (Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine)
  • 노장호 (연세대학교 의과대학 마취통증의학교실) ;
  • 최동훈 (연세대학교 의과대학 마취통증의학교실) ;
  • 이윤우 (연세대학교 의과대학 마취통증의학교실) ;
  • 윤덕미 (연세대학교 의과대학 마취통증의학교실)
  • Received : 2005.04.08
  • Accepted : 2005.05.24
  • Published : 2005.06.30
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Abstract

Background: Previous studies have suggested synergistic analgesic drug interactions between NSAIDs and opioids in neuropathic and inflammatory pain models. The aim of this study was to investigate the analgesic drug interaction between intraperitoneal (IP) ketorolac and morphine in radiant thermal stimulation rat. Methods: Initially, we assessed the withdrawal latency time of the hindpaw to radiant thermal stimulation every 15 min for 1 hour and every 30 min for next 1 hour after IP normal saline 5 ml (control group). The latency time was changed into percent maximal possible effect (%MPE). Next, IP dose response curves were established for the %MPE of morphine (0.3, 1, 3, 10 mg/kg) and ketorolac (3, 10, 30 mg/kg) to obtain the $ED_{50}$ for each agent. And we confirmed that the IP morphine effect was induced by opioid receptor through IP morphine followed by IP naloxone. At last, we injected three doses of IP ketorolac (3, 10, 30 mg/kg) mixed with one dose of morphine (2 mg/kg) for fixed dose analysis. Results: IP morphine delayed the paw withdrawal latency time dose dependently, but not ketorolac. $ED_{50}$ of IP morphine was 2.1 mg/kg. And the IP morphine effect was reversed to control level by IP naloxone. IP ketorolac + morphine combination showed no further additional effects on paw withdrawal latency time over morphine only group. Conclusions: IP ketorolac did not produce antinociceptive effect during radiant thermal stimulation. There was neither additional nor synergistic analgesic interaction between IP morphine and ketorolac in thermal stimulation rat.

Keywords

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