Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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8세 이상 소아에서의 가와사끼병의 임상 역학적 연구

Clinical and Epidemiologic Study of Kawasaki Disease in Children 8 Years of Age and Older

  • 박용원 (인제대학교 의과대학 소아과학교실) ;
  • 한지환 (가톨릭대학교 의과대학 소아과학교실) ;
  • 박인숙 (울산대학교 의과대학 소아과학교실) ;
  • 김창휘 (순천향대학교 의과대학 소아과학교실) ;
  • 차성호 (경희대학교 의과대학 소아과학교실) ;
  • 마재숙 (전남대학교 의과대학 소아과학교실) ;
  • 권태찬 (계명대학교 의과대학 소아과학교실) ;
  • 이상범 (경북대학교 의과대학 소아과학교실) ;
  • 김철호 (인제대학교 의과대학 소아과학교실) ;
  • 이홍재 (성균관대학교 의과대학 소아과학교실) ;
  • 윤용수 (서울대학교 의과대학 소아과학교실)
  • Park, Yong Won (Department of Pediatrics, College of Medicine, Inje University, Seoul Paik Hospital) ;
  • Han, Ji Whan (Department of Pediatrics, College of Medicine, Catholic University) ;
  • Park, In Sook (Department of Pediatrics, College of Medicine, University of Ulsan) ;
  • Kim, Chang Hwi (Department of Pediatrics, College of Medicine, Soonchunhyang University) ;
  • Cha, Sung Ho (Department of Pediatrics, College of Medicine, Kyunghee University) ;
  • Ma, Jae Sook (Department of Pediatrics, College of Medicine, Chonnam National University) ;
  • Kwon, Tae Chan (Department of Pediatrics, College of Medicine, Keimyung University) ;
  • Lee, Sang Bum (Department of Pediatrics, College of Medicine, Kyungpook National University) ;
  • Kim, Chul Ho (Department of Pediatrics, College of Medicine, Inje University, Seoul Paik Hospital) ;
  • Lee, Heung Jae (Department of Pediatrics, College of Medicine, Sungkyunkwan University) ;
  • Yun, Yong Soo (Department of Pediatrics, College of Medicine, Seoul National University)
  • 투고 : 2005.06.08
  • 심사 : 2005.08.01
  • 발행 : 2005.10.15
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초록

목 적 : 치명적인 관상동맥 합병증을 일으킬 수 있는 가와사끼병에 있어, 8세 이상 소아에서의 역학 및 임상적 특성을 알아보기 위하여 본 연구를 시행하였다. 방 법 : 대한 소아심장 학회의 주관하에 시행되는 가와사끼병의 국내 역학조사에서, 1994-2002년까지 9년간의 전체 환아 15,692례 중 발병 연령이 8세 이상인 환아 211례를 대상으로 하여 조사하였으며, 이를 8세 미만인 환아군과도 비교분석을 하였다. 결 과 : 전체 환아 15,692례 중 1.3%인 211례가 8세 이상으로, 평균 연령은 9.8세였으며, 8-10세가 142명, 10-12세가 42명, 12세 이상이 27명인 분포를 보였다. 남녀비는 1.9, 재발률은 3.8%였고 가족례는 없었다. 심에코검사상 25.4%의 관상동맥 이상 소견 및 7.6%의 관상동맥류 발생빈도를 나타냈으며 심근경색은 1례에서 있었다. 반면 대부분을 차지하는 8세 미만인 군은 남녀비 1.5, 재발률은 2.6%, 가족례 0.2%, 관상동맥 이상소견 19.8%, 관상동맥류 4.0%의 소견을 보였다. 결 론 : 8세 미만인 환아군과 비교해 본 결과, 8세 이상 환아군의 관상동맥 이상소견과 관상동맥류의 발생에 있어서 통계적으로 의미 있게 높은 빈도를 나타내었다.

Purpose : The aim of this study was to investigate the epidemiologic and clinical profiles of Kawasaki disease(KD) in children 8 years of age and older. Methods : For the epidemiologic study of KD in Korea, data of total 15,692 KD patients were collected from 1994 to 2002 on a 3 year basis, by the retrospective survey. Among them, data of 211 KD patients 8 years of age and older were analyzed and compared with those of the KD patients less than 8 years of age. Results : 211 patients 8 years of age and older(1.3% of total KD patients) with the mean age of 9.8 years, included 142 cases aged 8-10 years, 42 cases aged 10-12 years, and 27 cases aged 12 years and older. The male-to-female ratio was 1.9 : 1, the recurrence rate was 3.8%, and the prevalence of cases in sibling was zero. Coronary arterial(CA) abnormalities were detected by echocardiography in 25.4% of the cases, including 7.6% of CA aneurysm cases. There was 1 case complicated by myocardial infarction. Conclusion : Comparing with the data of the KD patients less than 8 years of age, data of 211 patients 8 years of age and older showed significantly higher incidences of CA abnormalities(25.4% : 19.8%) and CA aneurysms(7.6% : 4.0%).

키워드

과제정보

연구 과제 주관 기관 : 인제대학교

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