The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Assessment for the Role of Serotonin Receptor Subtype 3 for the Analgesic Action of Morphine at the Spinal Level

척수 수준에서 Morphine 의 진통 작용에 대한 Serotonin 3형 수용체 역할에 작용에 대한 평가

  • Yoon, Myung Ha (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Bae, Hong Buem (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Choi, Jeong Il (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Seok Jae (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Chang Mo (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Jeong, Sung Tae (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Kwang Su (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Jin, Won Jong (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Jong Pil (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Jong Sik (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Se Yeol (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Jeong, Chang Young (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University)
  • 윤명하 (전남대학교 의과대학 마취통증의학교실) ;
  • 배홍범 (전남대학교 의과대학 마취통증의학교실) ;
  • 최정일 (전남대학교 의과대학 마취통증의학교실) ;
  • 김석재 (전남대학교 의과대학 마취통증의학교실) ;
  • 김창모 (전남대학교 의과대학 마취통증의학교실) ;
  • 정성태 (전남대학교 의과대학 마취통증의학교실) ;
  • 김광수 (전남대학교 의과대학 마취통증의학교실) ;
  • 진원종 (전남대학교 의과대학 마취통증의학교실) ;
  • 김종필 (전남대학교 의과대학 마취통증의학교실) ;
  • 김종식 (전남대학교 의과대학 마취통증의학교실) ;
  • 김세열 (전남대학교 의과대학 마취통증의학교실) ;
  • 정창영 (전남대학교 의과대학 마취통증의학교실)
  • Received : 2005.09.05
  • Accepted : 2005.12.01
  • Published : 2005.12.10
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Abstract

Background: Serotonin 3 receptor is involved in the modulation of nociceptive transmission in the spinal cord. The serotonin 3 receptor antagonist has been used for the management of opioid-induced nausea and vomiting. The aim of this study was to examine whether the analgesic effect of morphine is antagonized by serotonin 3 receptor antagonists at the spinal level. Methods: Rats were implanted with lumbar intrathecal catheters. For nociception, a formalin solution (5%, $50{\mu}l$) was injected into the hind paw of male Sprague-Dawley rats. To determine whether the effect of intrathecal morphine was mediated via serotonin 3 receptors, serotonin 3 receptor antagonists were intrathecally administered 10 min prior to the morphine delivery. Following the formalin injection, formalin-induced nociceptive behavior (flinching response) was observed for 60 min. Results: Intrathecal morphine produced a dose-dependent suppression of the flinches in both phases during the formalin test. The analgesic action of morphine was not reversed by serotonin 3 receptor antagonists (LY-278,584, ondansetron), which had little per se effect on the formalin-induced nociception. Conclusions: Spinal serotonin 3 receptors may not be involved in the analgesia of morphine on a nociceptive state evoked by a formalin stimulus.

Keywords

Acknowledgement

Supported by : 전남대학교병원

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