Acknowledgement
Supported by : 대한소아과학회
References
-
Hagendorens MM, Van Bever HP, Schuerwegh AJ, De Clerck LS, Bridts CH, Stevens WJ. Determination of T-cell subpopulations and intracellular cytokine production(interleukin-2, interleukin-4, and interferon-
$\gamma$ ) by cord blood Tlymphocytes of neonates from atopic and non-atopic parents. Pediatr Allergy Immunol 2000;11:12-9 - Host A. Development of atopy in childhood. Allergy 1997;52:695-7. https://doi.org/10.1111/j.1398-9995.1997.tb01225.x
- Ricci M, Rossi O, Bertoni M, Matucci S. The importance of Th2-like cells in the pathogenesis of airway allergic inflammation. Clin Exp Allergy 1993;23:360-9 https://doi.org/10.1111/j.1365-2222.1993.tb00340.x
- Mosmann TR, Sad S. The expanding universe of T-cell subsets : Th1, Th2 and more. Immunol Today 1996;17:138-46 https://doi.org/10.1016/0167-5699(96)80606-2
- Kopp MV, Zehle C, Pichler J, Szepfalusi Z, Moseler M, Deichmann K, et al. Allergen-specific T cell reactivity in cord blood : the influence of maternal cytokine production. Clin Exp Allergy 2001;31:1536-43. https://doi.org/10.1046/j.1365-2222.2001.01198.x
- Kass SU, Pruss D, Wolffe AP. How does DNA methylation repress transcription? Trends Genet 1997;13:444-9 https://doi.org/10.1016/S0168-9525(97)01268-7
- Bird JJ, Brown DR, Mullen AC, Moskowitz NH, Mahowald MA, Sider JR, et al. Helper T cell differentiation is controlled by the cell cycle. Immunity 1998;9:229-37 https://doi.org/10.1016/S1074-7613(00)80605-6
- Li E. The mojo of methylation. Nat Genet 199;23:5-6 https://doi.org/10.1038/12595
- Bullens DMA, Rafiq K, Kasran A, van Gool SW, Ceuppens JL. Naive human T cells can be a source of IL-4 during primary immune responses. Clin Exp Immunol 1999;118: 384-91 https://doi.org/10.1046/j.1365-2249.1999.01072.x
- Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M. A mammalian protein with specific demethylase activity for mCpG DNA. Nature 1999;397:579-69 https://doi.org/10.1038/17492
- Santangelo S, Cousins DJ, Winkelmann NEE, Staynov DZ. DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4+ T cell differentiation. J Immunol 2002;169:1893-903
- Hide DW, Arshad SH, Twiselton R, Stevens M. Cord serum IgE : an insensitive method for prediction of atopy. Clin Exp Allergy 1991;21:739-45 https://doi.org/10.1111/j.1365-2222.1991.tb03204.x
- Kjellman NIM, Croner S. cord blood IgE determination for allergy prediction-a follow-up to seven years of age in 1,651 children. Ann Allergy 1984;53:167-74
- Kondo N, Kobayashi Y, Shinoda S. Cord blood lymphocyte responses to food antigens for the prediction of allergic disorders. Arch Dis Child 1992;67:1003-7 https://doi.org/10.1136/adc.67.8.1003
- Yabuhara A, Macaubas C, Prescott SL, Venaille TJ, Holt BJ, Habre W, et al. Th2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood. Clin Exp Allergy 1997;27:1261-9 https://doi.org/10.1111/j.1365-2222.1997.tb01170.x
- Maggi E, Parronchi P, Manetti P. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992;148:2142-7
- Rengarajan J, Szabo SJ, Glimcher LH. Transcriptional regulation of Th1/Th2 polarization. Immunol Today 2000;21: 479-83 https://doi.org/10.1016/S0167-5699(00)01712-6
- Grogan JL, Locksley RM. T helper cell differentiation : on again, off again. Curr Opin Immunol 2002;14:366-72 https://doi.org/10.1016/S0952-7915(02)00340-0
- Guo L, Hu-Li J, Zhu J, Watson CJ, Difilippantonia MJ, Pannetier C, et al. In Th2 cells the IL4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 prodution. PNAS 2002;99:10623-8 https://doi.org/10.1073/pnas.162360199
- Lee DU, Agarwal S, Rao A. The lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 2002;16:649-60 https://doi.org/10.1016/S1074-7613(02)00314-X
- Cedar H, Verdine GL. The amazing demethylase. Nature 1999;397:568-569 https://doi.org/10.1038/17492
- Danbara M, Kameyama K, Higashihara M, Takagaki Y. DNA methylation dominates transcriptiona silencing of Pax5 in terminally differentiated B cell lines. Mole Immunol 2001;38:1161-6