Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Comparative Studies on the Relative Efficacy of DL-methionine and Liquid Methionine Hydroxy Analogue in Growing Pigs

  • Zimmermann, B. (University of Hohenheim, Institute of Animal Nutrition) ;
  • Mosenthin, R. (University of Hohenheim, Institute of Animal Nutrition) ;
  • Rademacher, M. (Degussa AG) ;
  • Lynch, P.B. (Teagasc, Moorepark Research Centre) ;
  • Esteve-Garcia, E. (Department of Animal Nutrition, IRTA)
  • Received : 2004.09.22
  • Accepted : 2005.01.28
  • Published : 2005.07.01
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Abstract

A study consisting of 3 trials was designed to assess the relative biological efficacy of DL-methionine (DL-Met) in comparison to liquid methionine hydroxy analogue (MHA-FA) in growing pigs. In trial I a basal diet was supplemented with three graded levels of DL-methionine (0.25, 0.50 and 0.75 g/kg) or liquid MHA-FA (0.0285, 0.0570 and 0.0855 g/kg) on equimolar basis. The basal diet contained 18.3% CP, 0.22% Met and 0.51% Met+Cys, which is below the methionine requirement for weaned pigs between 10 and 20 kg BW according to NRC (1998) but adequate in all other essential nutrients and energy. Using an exponential model, the efficacy of the two methionine sources was estimated from nitrogen retention data obtained in 42 piglets with an initial BW between 11.0 kg (Exp. 1) and 11.7 kg (Exp. 2). In trials II and III, with a total of 192 and 96 pigs, and with an initial BW of 10.6 and 21 kg, respectively, growth response criteria were assessed to determine if in agreement with previous studies in pigs and poultry a biological effectiveness of about 65% on average could be confirmed for liquid MHA-FA in comparison to DL-met. Based on N-retention (trial I) the biological efficacy of liquid MHA-FA on a weight-to-weight basis was calculated to be 62% relative to DL-met. Basically, these results were confirmed using growth response criteria as measures; the results of trial II and III revealed no significant differences in growth performance and feed conversion between treatments indicating that 100 parts of liquid MHA-FA can be replaced by 65 parts of DL-met.

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References

  1. Boling, S. D., H. M. Edwards III, J. L. Emmert, R. R. Riehl and D. H. Baker. 1998. Bioavailability of iron in cottonseed meal, ferric sulfate and two ferrous sulfate by-products of the galvanizing industry. Poult. Sci. 77:1388-1392.
  2. Chung, T. K. and D. H. Baker. 1992. Utilization of methionine isomers and analogy by the pig. Can. J. Anim. Sci. 72:185-188.
  3. Commission Directive. 1998. Establishing community methods for the determination of amino-acids, crude oils and fats, and olanquindox in feeding stuff and amending Directive 71/393/EEC, annex part A. Determination of Amino Acids. Official Journal of the European Communities L257, pp. 14-23.
  4. Commission Directive. 2000. Establishing community methods for the determination of vitamin A, vitamin E and tryptophan, annex part C. Determination of Tryptophan. Official Journal of the European Communities L174, pp. 45-50.
  5. Centraal Veevoeder Bureau (CVB). 2003. Tabellenboek Veevoeding, Lelystad, The Netherlands.
  6. Dibner, J. J. and C. D. Knight. 1984. Conversion of 2-hydroxy-4- (methylthio)butanoic acid to L-methionine in the chick: A stereospecific pathway. J. Nutr. 114:1716-1723.
  7. Esteve-Garcia, E. and R. E. Austic. 1993. Intestinal absorption and renal excretion of dietary methionine sources by the growing chicken. J. Nutr. Biochem. 4:576-587.
  8. Esteve-Garcia, E. and L. Llaurado. 1997. Performance, breast meat yield and abdominal fat deposition of male broiler chickens fed diets supplemented with DL-methionine or DLmethionine hydroxy analogue free acid. Br. Poult. Sci. 38:397-404.
  9. Fabian, J., L. I. Chiba, D. L. Kuhlers, L. T. Frobish, K. Nadarajah, C. R. Kerth, W. H. McElhenney and A. J. Lewis. 2002. Degree of amino acid restrictions during the grower phase and compensatory growth in pigs selected for lean growth efficiency. J. Anim. Sci. 80:2610-2618.
  10. Fandrejewski, H. and A. Rymarz. 1986. Effect of feeding level on Ca, P, K and Na content in the bodies of growing boars and gilts. Livest. Prod. Sci. 14:211-215.
  11. Huyghebaert, G. 1993. Comparison of DL-methionine and methionine hydroxy analogue-free acid in broilers by using multi-exponential regression models. Br. Poult. Sci. 34:351-359.
  12. Imbeah, M., W. C. Sauer and R. Mosenthin. 1988. The prediction of the digestible amino acid supply in barley-soybean meal or canola diets and pancreatic enzyme secretion in pigs. J. Anim. Sci. 66:1409-1417.
  13. Institut National de la Recherche Agronomique (INRA). 1984. L'alimentation des animaux monogastrique : porc, lapin volailles. Paris, La France.
  14. Kemme, P. A., J. S. Radcliffe, A. W. Jongbloed and Z. Mroz. 1994. Factors affecting phosphorus and calcium digestibility in diets for growing-finishing pigs. J. Anim. Sci. 75:2139-2146.
  15. Knight, C. D. and J. J. Dibner. 1984. Comparative absorption of 2-hydroxy-4-(methylthio)-butanoic acid and L-methionine in the broiler chick. J. Nutr. 114:2179-2186.
  16. Knight, C. D., C. A. Atwell, C. W. Wuelling, F. J. Ivey and J. J. Dibner. 1998. The relative effectiveness of 2-hydroxy-4-(methylthio) butanoic acid and DL-methionine in young swine. J. Anim. Sci. 76:781-787.
  17. Lemme, A., D. Hoehler, J. J. Brennan and P. F. Mannion. 2002. Relative effectiveness of methionine hydroxy analog compared to DL-methionine in broiler chickens. Poult. Sci. 81:838-845.
  18. Lemme, A., M. Pack, S. Mack, D. D. Maenz and M. D. Drew. 2001. The impact of intestinal bacteria on absorption of different methionine sources in growing germ-free and conventional broiler chicken. In: Proc. Nutr. Soc. 10:112.
  19. Lingens, G. and S. Molnar. 1996. Studies on metabolism of broilers by using 14-labelled DL-methionine and DLmethionine hydroxy analog Ca-salt. Arch. Anim. Nutr. 49:113-124.
  20. Littell, R. C., P. R. Henry, A. J. Lewis and C. B. Ammerman. 1997. Estimation of relative bioavailability of nutrients using SAS procedures. J. Anim. Sci. 75:2672-2683.
  21. Llames, C. R. and J. Fontaine. 1994. Determination of amino acids in feeds: collaborative study. J. Assoc. Off. Anal. Chem. Intern. 77:1362-1402.
  22. Lorz, A. and E. Metzger. 1999. Tierschutzgesetz: Tierschutzgesetz mit Allgemeiner Verwaltungsvorschrift, Rechtsverordnungen und Europaeischen Uebereinkommen. Kommentar. 5 Neubearbeitete Auflage, Beck Verlag, Muenchen, Germany (in German).
  23. Maenz, D. D. and C. M. Engele-Schaan. 1996a. Methionine and 2-hydroxy-4-methylthiobutanoic acid are transported by distinct $NA^+$-dependent and $H^+$-dependent systems in the brush border membrane of the chick intestinal epithelium. J. Nutr. 126:529-536.
  24. Maenz, D. D. and C. M. Engele-Schaan. 1996b. Methionine and 2-hydroxy-4-methylthiobutanoic acid are partially converted to nonabsorbed compounds during passage through the small intestine and heat exposure does not affect small intestinal absorption of methionine sources in broiler chicks. J. Nutr. 126:1438-1444.
  25. Mandal, A. B., A. V. Elangovan and T. S. Johri. 2004. Comparing bio-efficacy of liquid DL- methionine hydroxy analogue free acid with DL-methionine in broiler chickens. Asian-Aust. J. Anim. Sci. 17:102-108. https://doi.org/10.5713/ajas.2004.102
  26. National Research Council (NRC). 1998. Nutrient Requirements of Swine. 10th Ed. National Academy Press, Washington, DC.
  27. Naumann, K., R. Bassler, R. Seibold and K. Barth. 1976. VDLUFA-Methodenbuch Band III. Die chemische Untersuchung von Futtermitteln. Mit Ergaenzungslieferungen 1983, 1988, 1993, 1997. VDLUFA-Verlag, Darmstadt, Germany (in German).
  28. Owen, K. Q., R. D. Goodband, J. L. Nelssen, M. D. Tokach and S. S. Dritz. 1995a. The effect of dietary methionine and its relationship to lysine on growth performance of the segretated early-weaned pig. J. Anim. Sci. 73:3666-3972.
  29. Owen, K. Q., J. L. Nelssen, R. D. Goodband, M. D. Tokach, L. J. Kats and K. G. Friesen. 1995b. Added dietary methionine in starter pig diets containing spray-dried blood products. J. Anim. Sci. 73:2647-2654.
  30. Roemer, A. and H. J. Abel. 1996. N-Bilanzversuche zur Ergaenzungswirkung von Methioninhydroxyanalog (MHA) und DL-Methionin bei wachsenden Schweinen (N-balance trials on the supplemental effect of MHA and DL-methionine in growing pigs). In: Proc. Nutr. Soc. 5:49 (in German).
  31. Roemer, A. and H. J. Abel. 1999. Effects of DL-methionine hydroxyanalogue (MHA) or DL-methionine (DL-Met) on Nretention in broiler chickens and pigs. Anim. Feed Sci. Technol. 81:193-203.
  32. Roth, F. X. and M. Kirchgessner. 1986. Relative biological efficiency of methionine hydroxy analogue-free acid for growing pigs. J. Anim. Physiol. Anim. Nutr. 55:93-100.
  33. SAS Institute Inc. 1996. SAS/STAT, User’s Guide: Version 6. 12th edn. SAS Institute Inc., Cary, North Carolina.
  34. Saunderson, C. L. 1991. Metabolism of methionine and its nutritional analogs. Poult. Int. 30 (13):34-38.
  35. Schmidt, J. 2000. Nitrogen retention in pigs fed different methionine sources. Report University of West Hungary, Mosonmagyarovar.
  36. Steinhart, H. and M. Kirchgessner. 1985. Biologische Wirksamkeit von DL-Methionin-Na und DL-2Hydroxy-4 methylmercaptobuttersaeure bei Ferkeln. J. Anim. Physiol. Anim. Nutr. 53:104-110 (in German).
  37. Stockland, W. L., G. L. Asche, W. W. Robey and E. E. Pierson. 1992. Methionine hydroxy analogue-calcium effective for growing pigs. Feedstuffs 64 (January, 13):11-12.
  38. Van Weerden, E. J., J. B. Schutte and H. L. Bertram. 1992. Utilization of the polymers of methionine hydroxy analog free acid (MHA-FA) in broiler chicks. Arch. Geflügelkde. 56:63-68.
  39. Wallis, I. R. 1999. Dietary supplements of methionine increase breast meat yield and decrease abdominal fat in growing broiler chickens. Aust. J. Exp. Agric. 39:131-141. https://doi.org/10.1071/EA98130
  40. Walz, O. P. and J. Pallauf. 1996. Wirkungsvergleich von DLMethionin und Methionin-Hydroxyanalog in Rationen mit Ackerbohnen und Erbsen bei Ferkeln und Mastschweinen. In: VDLUFA-Schriftenreihe 44, Kongressband, Trier. pp. 155-158 (in German).
  41. Zimmermann, B., H.-J. Lantzsch, R. Mosenthin, F.-J. Schoner, H. K. Biesalski and W. Drochner. 2002. Comparative evaluation of the efficacy of cereal and microbial phytases in growing pigs fed diets with marginal phosphorus supply. J. Sci. Food Agric. 82:1298-1304.

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