Near-Infrared Light Propagation in an Adult Head Model with Refractive Index Mismatch

  • Received : 2004.05.11
  • Published : 2005.08.31

Abstract

We investigate near-infrared light (NIR) propagation in a model of an adult head using an extensive Monte Carlo (MC) simulation. The adult head model is a four-layered slab which consists of a surface layer, a cerebrospinal fluid layer, a gray-matter layer, and a white-matter layer. We study the effects of a refractive index mismatch on the model, calculating the intensity of detected light, mean flight time, and partial mean flight time of each layer for various refractive indices of the cerebrospinal fluid layer as functions of source-detector spacing. The Monte Carlo simulation shows that the refractive index mismatch presents very rich results including rapidly decaying intensity of detected light and a peak and cross-over in the partial mean flight time with source-detector spacing. We also investigate spatial sensitivity profiles at various source-detector spacings, discussing the index mismatch effect on the model.

Keywords

References

  1. Ann. Biomed. Eng. v.14 no.2 In Vivo Photometric Analysis of Hemoglobin Pittman, R.N.
  2. IEEE Trans. Biomed. Eng. v.38 no.12 Simple Photon Diffusion Analysis of the Effects of Multiple Scattering on Pulse Oximetry Schmitt, J.M.
  3. Med. Phys. v.27 no.2 Oximetry Based on Diffuse Photon Density Wave Differentials Ntziachristos, V.;Kohl, M.;Ma, H.;Chance, B.
  4. Pediatrics v.25 no.2 Noninvasive Monitoring of Cerebral Oxygenation in Preterm Infants: Preliminary Observations Brazy, J.E.;Lewis, D.V.;Mitnick, M.H.;Jobsis vander Vliet, F.F.
  5. Lancet v.2 no.8515 Quantification of Cerebral Oxygenation and Haemodynamics in Sick Newborn Infants by Near Infrared Spectroscopy Wyatt, J.S.;Delpy, D.T.;Cope, M.;Wray, S.;Reynolds, E.O.R.
  6. Adv. Exp. Med. Biol. v.200 Effect of Cartid Artery Compression Test on Regional Cerebral Blood Volume, Haemoglobin Oxygen Saturation and Cytochrome-c-oxidase Redox Level in Cerebrovascular Patients Ferrari, M.;Zanette, E.;Giannini, I.;Sideri, G.;Fieschi, C.;Carpi, A.
  7. J. Appl. Physiol. v.69 no.3 Cerebral Oxygen Availability by NIR Spectroscopy during Transient Hypoxia in Humans Hampson, N.B.;Camporesi, E.M.;Stolp, B.W.;Moon, R.E.;Shook, J.E.;Griebel, J.A.;Piantadosi, C.A.
  8. Neurosci. Lett. v.150 no.1 Detection of Dynamic Changes in Cerebral Oxygenation Coupled to Neuronal Function during Mental Work in Man Hoshi, Y.;Tamura, M.
  9. Appl. Opt. v.37 no.10 Assessment of the Size, Position, and Optical Properties of Breast Tumor in Vivo by Noninvasive Optical Methods Fantini, S.;Walker, S.A.;Franceschini, M.A.;Kaschke, M.;Schlag, P.M.;Moesta, K.T.
  10. IEEE Trans. Med. Imaging v.20 no.12 Three-dimensional optical tomographic imaging of breast in a human subject Jiang, H.;Xu, Y.;Iftimia, N. V.;Eggert, J.A.;Klove, K.L.;Baron, L.;Fajardo, L.
  11. Acad. Radiol. v.9 no.2 Near-Infrared Optical Imaging of the Breast with Model-Based Reconstruction Jiang, H.;Iftimia, N.V.;Xu, Y.;Eggert, J.A.;Fajardo, L.L.;Klove, K.L.
  12. IEEE J. Quantum Electron. v.26 no.12 A Review of the Optical Properties of Biological Tissues Cheong, W.;Prahl, S.A.;Welch, A.J.
  13. Appl. Opt. v.22 no.16 Scattering and Absorption of Turbid Materials Determined from Reflection Measurements. 1. Theory Groenhuis, R.A.J.;Ferwada, H.A.;Ten Bosch, J.J.
  14. Appl. Opt. v.22 no.16 Scattering and Absorption of Turbid Materials Determined from Reflection Measurements.2. Measuring Method and Calibration Groenhuis, R.A.J.;Ferwada, H.A.;Ten Bosch, J.J.
  15. Phys. Med. Biol. v.42 no.12 Expression of Optical Diffusion Coefficient in High-Absorption Turbid Media Nakai, T.;Nishimura, G.;Yamamoto, K.;Tamura, M.
  16. Opt. Lett. v.22 no.12 Indepdence of the Diffusion Coefficient from Absorption: Experimental and Numerical Bassani, M.;Martelli, F.;Zaccanit, G.;Contini, D.
  17. Med. Phys. v.20 no.1 A Finite Element Approach for Modeling Photon Transport in Tissue Arridge, S.R.;Schweiger, M.;Hiraoka, M.;Delpy, D.T.
  18. Med. Phys. v.22 no.6 Spatially Varying Optical Property Reconstruction Using a Finite Element Diffusion Equation Approximation Paulsen, K.D.;Jiang, H.
  19. Phys. Med. Biol. v.40 no.9 Statistical Basis for the Determination of Optical Pathlength in Tissue Arridge, S.R.;Hiraoka, M.;Schweiger, M.
  20. J. Biomed. Opt. v.5 no.2 Photon Migration through Fetal Head in Utero Using Continuous Wave, Near-Infrared Spectroscopy:Development and Evaluation of Experimental and Numerical Models Vishnoi, G.;Hielscher, A.H.;Ramanujam, N.;Chance, B.
  21. Phys. Med. Biol. v.45 no.12 Optical Non-Invasive Technique for Vessel Imaging: II. A Simplified Photon Diffusion Analysis Fridolin, I.;Hansson, K.;Lindberg, L.G.
  22. Phys. Med. Biol. v.41 An Investigation of Light Transport through Scattering Bodies with Non-Scattering Regions Firbank, M.;Arridge, S.R.;Schweiger, M.;Delpy, D.T.
  23. Med. Phys. v.27 The Finite Element Model for the Propagation of Light in Scattering Media: a Direct Method for Domains with Nonscattering Regions Arridge, S.R.;Dehghani, H.;Schweiger, M.;Okada, E.
  24. J. Opt. Soc. Am. A v.17 no.9 Boundary Conditions for Light Propagation in Diffusive Media with Nonscattering Regions Ripoll, J.;Nieto Vesperinas, M.;Arridge, S.R.;Dehghani, H.
  25. Appl. Opt. v.36 no.1 Theoretical and Experimental Investigation of Near-Infrared Light Propagation in a Model of the Adult Head Okada, E.;Firbank, M.;Schweiger, M.;Arridge, S.R.;Cope, M.;Delpy, D.T.
  26. J. Opt. Soc. Am. A v.16 no.8 Index Mismatch for Diffuse Photon Density Waves at Both Flat and Rough Diffuse-Diffuse Interfaces Ripoll, J.;Nieto Vesperinas, M.
  27. Appl. Opt. v.39 no.25 Near-Infrared Spectroscopy of the Adult Head: Effect of Scattering and Absorbing Obstructions in the Crebrospinal Fuid Lyer on Lght Dstribution in the Tssue Dehghani, H.;Delpy, D.T.
  28. Photon Migration and Imaging in Random Media and Tissues, Proc. SPIE v.1888 Optical Properties of Brain Tissue van der Zee, P.;Essenpreis, M.;Delpy, D.T.;Alfano, R.R.(ed.);Chance, B.(ed.)
  29. Phys. Med. Biol. v.38 no.4 Measurement of the Optical Properties of the Skull in the Wavelength Range 650-950 nm Firbank, M.;Hiraoka, M.;Essenpreis, M.;Delpy, D.T.
  30. Computer Methods and Programs in Biomedicine v.47 no.2 MCML - Monte Carlo Modeling of Photon Transport in Multi-Layered Tissues Wang, L.H.;Jacques, S.L.;Zheng, L.Q.
  31. Computer Methods and Programs in Biomedicine v.54 no.3 CONV - Convolution for Responses to a Finite Diameter Photon Beam Incident on Multi-Layered Tissues Wang, L.H.;Jacques, S.L.;Zheng, L.Q.