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Transforming Growth Factor-β: Biology and Clinical Relevance

  • YiKim, Isaac (Department of Urology, University of California at Irvine) ;
  • Kim, Moses M. (Scott Department of Urology, Baylor College of Medicine) ;
  • Kim, Seong-Jin (Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute)
  • Published : 2005.01.31
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Abstract

Transforming growth factor-$\beta$ is a pleiotropic growth factor that has enthralled many investigators for approximately two decades. In addition to many reports that have clarified the basic mechanism of transforming growth factor-$\beta$ signal transduction, numerous laboratories have published on the clinical implication/application of transforming growth factor-$\beta$. To name a few, dysregulation of transforming growth factor-$\beta$ signaling plays a role in carcinogenesis, autoimmunity, angiogenesis, and wound healing. In this report, we will review these clinical implications of transforming growth factor-$\beta$.

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References

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