Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Inhibitory Effect of Ruta chalepensis Leaf-Derived Component against Alcohol Dehydrogenase

  • Jeon, Ju-Hyun (Faculty of Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University) ;
  • Cho, Jang-Hee (Faculty of Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University) ;
  • Kim, Hyo-Gyung (Faculty of Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University) ;
  • Lee, Hoi-Seon (Faculty of Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University)
  • Published : 2005.12.31
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Abstract

Inhibitory activity of active compound isolated from Ruta chalepensis leaf was examined against alcohol dehydrogenase and, upon comparison to those of four commercially available compounds (quinoline, quinoline-3-carboxaldehyde, quinoline-3-carboxylic acid, and quinoline-4-carboxylic acid) and 1,10-phenanthroline as alcohol dehydrogenase inhibitor, was characterized as quinoline-4-caboxaldehyde by spectral analyses. Inhibitory effects ($IC_{50}$) of quinoline-4-caboxaldehyde and quinoline derivatives varied depending on chemicals and concentrations used. The $IC_{50}$ values of quinoline-4-carboxaldehyde, quinoline-3-carboxaldehyde, quinoline, quinoline-3-carboxylic acid, and quinoline-4-carboxylic acid were 0.04, 0.3, 0.8, >1, and >1 mg/mL, respectively. These results suggest inhibitory action of quinoline-4-carboxaldehyde against alcohol dehydrogenase as prospective therapeutics for treatment of alcoholic liver diseases such as alcohol hepatitis and cirrhosis resulting from chronic alcohol abuse.

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