Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Induction of Neurite Outgrowth by (-)-(7R, 8S)-Dihydrodehyd­rodiconiferyl Alcohol from PC12 Cells

  • Shin Jung Soo (Research Center for Bioresource and Health, Chungbuk National University) ;
  • Kim Yu Mi (Research Center for Bioresource and Health, Chungbuk National University) ;
  • Hong Seong Su (College of Pharmacy, Chungbuk National University) ;
  • Kang Ho Sang (Department of Silviculture and Restoration Ecology, College of Agriculture and Life Sciences, Seoul National University) ;
  • Yang Yoo Jung (Research Center for Bioresource and Health, Chungbuk National University) ;
  • Lee Don Koo (Department of Silviculture and Restoration Ecology, College of Agriculture and Life Sciences, Seoul National University) ;
  • Hwang Bang Yeon (College of Pharmacy, Chungbuk National University) ;
  • Ro Jai Seup (College of Pharmacy, Chungbuk National University) ;
  • Lee Myung Koo (Research Center for Bioresource and Health, Chungbuk National University)
  • Published : 2005.12.01
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Abstract

A lignan derivative, (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol (DHDA), was isolated from Kalopanax septemlobus L. and was observed to have neuritogenic activity. DHDA at 50 $\mu$M caused a marked induction of neurite outgrowth and an enhancement of nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. However, it did not exhibit any neurotrophic action. At 50 $\mu$M, DHDA enhanced NGF-induced neurite-bearing activity. This activity was partially blocked by the mitogen-activated protein kinase (MAPK) inhibitor PD98059 and by GF109203X, a protein kinase C (PKC) inhibitor. These results suggest that DHDA can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.

Keywords

References

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