YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of 3-Allylthio-6-heterocyclylalkylaminopyidazine Derivatives and their Anti-tumor Activities Against SK-Hep-1 Human Liver Cancer Cells

3-Allylthio-6-heterocyclylalkylaminopyridazine 유도체 합성 및 SK-Hep-1 인간간암세포에 대한 항암효과

  • 권순경 (덕성여자대학교 약학대학) ;
  • 이명숙 (덕성여자대학교 약학대학)
  • Published : 2005.12.01
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Abstract

Allylthio group of allicin and other organosulfur compounds which are isolated from garlic is considered as a pharmacophore, a key structure component of the molecule which is responsible biological activities. In the foregoing studies various 3-allylthio -6- alkoxypyridazine derivatives (K- compounds ) and 3-allylthio -6- alkylthiopyridazine derivatives(Thio-K-compounds) were synthesized and their biological activities were tested in vivo. They showed good hepatoprotective activities on the carbon tetrachloride-treated mouse and aflatoxin Bl-treated rat and chemopreventive activities on bepatocarcinoma cells in rat as expected. Now 3-allylthio-6-heterocyclylalkylaminopyridazine derivatives that the oxygen atom at 6-Position of 3-allylthio-6-alkoxypyridazine is replaced by nitrogen (N) were synthesiz ed and their activities were tested in vitro against SK-Hep-1 human liver cancer cells. They showed good chemopreventive activities on hepatocarcinoma cells.

Keywords

References

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