한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

  • 제34권9호
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  • Pages.1362-1366
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  • 2005
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  • 1226-3311(pISSN)
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  • 2288-5978(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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알코올을 투여한 당뇨 흰쥐의 혈당과 혈청지질에 미치는 홍삼 청국장 추출물의 영향

Effect of Red Ginseng-Chungkukjang Extracts on Lipid Profiles of Serum in Alcohol Administered Diabetes-Induced Rats

  • 이상일 (계명문화대학 식품영양조리과) ;
  • 신진기 (대구가톨릭대학교 식품산업학부 식품공학) ;
  • 김순동 (대구가톨릭대학교 식품산업학부 식품공학)
  • Lee, Sang-Il (Dept. of Food Nutrition & Cookery, Keimyung College) ;
  • Shin, Jin-Gi (Dept. of Food Science & Techology, Faculty of Food Industrial Technology, Catholic University of Daegu) ;
  • Kim, Soon-Dong (Dept. of Food Science & Techology, Faculty of Food Industrial Technology, Catholic University of Daegu)
  • 발행 : 2005.11.01
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초록

홍삼청국장 추출물(RC)이 알코올을 섭취중인 당뇨흰쥐 혈당과 혈청지혈에 미치는 효과를 관찰하기 위하여 SD계 흰쥐에 streptozotocin(STZ)을 투여하여 고혈당과 고지혈증을 유발시킨 다음 홍삼청국장 추출물을 함유(g/mL)하는 $20\%$ 알코올을 매일 2 mL씩 2주간 경구투여 하였을 때의 증체량, 식이효율, 음용수 섭취량과 배뇨량, 장기중량, 혈당 및 혈청지질 함량에 미치는 영향을 조사하였다. 그 결과 RC의 식이는 STZ 투여에 의하여 증가되었던 음용수 섭취량과 배뇨량을 개선시키지 못하였으나, 감소하였던 증체량과 식 이 효율은 대조군 수준으로 회복시켰으며, 고혈당과 고지혈증도 유의하게 감소시켰다. RC는 당뇨 유발 후 에탄을 투여로 인한 사망률을 현저히 감소시켰다. 이러한 결과와 문헌상의 지견들을 종합해 볼 때, RC는 고혈당 및 고지혈증을 치료 및 예방함으로서 에탄을 섭취에 의한 사망률을 감소시킴과 동시에 당뇨에 의해 발생할 수 있는 당뇨 합병증을 예방 내지는 지연시켜주는 작용이 있을 것으로 생각된다.

To evaluate red ginseng-chungkukjang extracts (RC) on levels of blood sugar and serum lipids in diabetes rats fed with ethanol, SD rats were supplemented 2 mL of $20\%$ ethanol solution with or without RC by gastric intubation for 2 weeks after streptozotocin (STZ) injection and then body weight gains, food efficiency ratio (FER), water intake, urine volume, organ weight, levels of blood sugar and serum lipids were determined. Water intake and urine volume were not restored in STZ-treated rats by RC supplementation. On the other hand, decreased body weight gam and FER were restored in diabetes rats by RC supplementation. Furthermore, levels of blood sugar, serum triglyceride, total cholesterol and LDL-cholesterol were significantly decreased by RC supplementation. The rate of mortality in diabetes rats was significantly inhibited by RC supplementation. These results suggest that inhibited rate of mortality in diabetes rats by supplementation of ethanol with RC was considered to be due to improvement of blood sugar and serum lipids levels by components of RC.

키워드

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