Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Porphyran Drink on Serum and Liver Cholesterol Contents in Hypercholesterolemic Rat

Porphyran 음료 투여가 고콜레스테롤 유발 흰쥐의 혈청과 간중의 콜레스테롤함량에 미치는 영향

  • Jung, Bok-Mi (Dept. of Food Science and Nutrition, Yosu National University) ;
  • Jung, Kyoo-Jin (Dept. of Hotel Culinary & Bakery, Provincial College of Namdo)
  • 정복미 (여수대학교 식품영양학과) ;
  • 정규진 (남도대학 호텔조리제빵과)
  • Published : 2005.11.01
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Abstract

This study investigated the effect of porphyran drink extracted from Porphyra yezoensis on serum and liver cholesterol contents in hypercholesterolemic rats. We divided rats into 5 diet groups; normal diet, control diet fed high cholesterol diet, $1\%$ porphyran drink diet with control diet $(1\%\;PD),\;2\%$ porphyran drink diet with control diet $(2\%\;PD),\;3\%$ porphyran drink diet with control diet ($3\%$ PD). Food intake was not significantly different among groups, but weight gain was significantly lower in porphyran drink group $(1\%,\;3\%)$ than control group. Liter weight was significantly lower in $3\%$ porphyran drink group than control group. Serum triglyceride and total cholesterol contents were significantly lower in porphyran drink group than control group. Serum HDL-cholesterol contents was elevated as porphyran drink intake level increased. Hepatic triglyceride and total cholesterol concentrations were significantly decreased in porphyran drink group compared to control diet. These results suggested that addition of porphyran drink in hypercholesterolemic rats has an effect on the improvement of serum and liver cholesterol.

본 연구는 김에서 추출한 porphyran을 음료로 이용하여 Sprague-Dawley계 흰쥐를 5군으로 나누어 정상식이에 물, 고콜레스테롤 식이에 물, 고콜레스테롤 식이에 1, 2, $3\%$ porphyran 음료를 4주간 급여하여 혈액과 간중의 지방과 콜레스테롤 함량을 측정한 결과는 다음과 같다. 혈청중 중성지방과 총콜레스테롤 함량은 정상군에 비해 대조군에서 높게 나타났으며, porphyran 음료군은 대조군보다 유의하게 낮았으며, 이는 섭취수준이 높을수록 더 낮아지는 경향을 나타냈다. 혈청중 HDL-콜레스테롤 함량은 대조군에서 가장 낮게 나타났으나 porphyran 음료 섭취수준이 높아질수록 높아지는 경향을 보였다. 간중의 중성지방과 총콜레스테롤 함량 역시 대조군에 비해 porphyran음료 섭취수준이 높을수록 유의하게 낮은 경향을 나타냈다. 이들 결과로 볼 때 고 콜레스테롤 식이를 섭취시킨 흰쥐에서 김에서 추출한 porphyran 을 음료의 형태로 섭취 시 체내 중성지방과 콜레스테롤을 낮추어 지방개선의 효과가 있음을 알 수 있었다.

Keywords

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