Biomedical Science Letters (대한의생명과학회지)
- Volume 11 Issue 4
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- Pages.509-515
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- 2005
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Changes of Hepatic Cyclohexane Metabolizing Enzyme Activities and Its Metabolites in Serum and Urine after Cyclohexane Treatment
- Kim Ji-Yeon (Department of Public Health, Keimyung University) ;
- Jeon Tae-Won (College of Pharmacy, Yeungam University) ;
- Lee SangHee (Department of Beauty Design, Kyongdo Provincial College) ;
- Chung Chinkap (Department of Chemistry, Keimyung University) ;
- Joh Hyun-Sung (Department of Oriental Medicine Resources, Asia University) ;
- Lee Sang-Il (Department of Food Nutrition and Cookery, Keimyung College) ;
- Yoon Chong-Guk (Department of Public Health, Keimyung University)
- Published : 2005.12.01
Abstract
This study was conducted to determine the kinetics of cyclohexane metabolites (the biomarker on cyclohexane exposure), the changes of hepatic cyclohexane metabolizing enzyme activities and the metabolites of cyclohexane in urine or serum. The rats were sacrificed at 2, 4, 8, 12 and 24 hr after administration of one dose of cyclohexane (1.56 g/kg body weight, i.p.). The metabolites of cyclohexane in urine were identified as cyclohexanol, cyclohexanone, trans-l,2-cyclohexanediol and 1,4-cyclohexanediol with cyclohexane metabolite being 124.00, 0.78, 23.28 and 2.75 (g/g of creatinine,
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