Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Antifungal Activity of 5 Antifungal Agents and Granitic Powder on Microsporum canis

Microsporum canis에 대한 5가지 항진균제와 맥반석 가루의 항진균 효과

  • Kang Tae-hyung (College of Veterinary Medicine, Chonnam National University) ;
  • Lee Jeong-chi (Department of Veterinary nurse and pets sciences, Seojeong College) ;
  • Won Young-ho (Department of Dermatology, Chonnam National University) ;
  • Oh Seok-il (The Jindo Research Center) ;
  • Lee Chung-gil (College of Veterinary Medicine, Chonnam National University) ;
  • Lee Chai-yong (College of Veterinary Medicine, Chonnam National University)
  • 강태형 (전남대학교 수의과대학) ;
  • 이정치 (서정대학 애완동물과) ;
  • 원영호 (전남대학교 의과대학 피부과학교실) ;
  • 오석일 (진도군 진돗개 시험연구소) ;
  • 이정길 (전남대학교 수의과대학) ;
  • 이채용 (전남대학교 수의과대학)
  • Published : 2005.12.01
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Abstract

The aim of this study was to determine tile inhibitory effect of granitic powder against Microsporum canis. Fourteen strains of M. canis isolated from dgs and cats with fungal dermatitis and two strains isolated from humans were used in this study. The in vitro antifungal activities of granitic powder and 5 commercialized antifungal agents (terbinafine, itraconazole, ketoconazole, griseofulvin and fluconazole) were compared. The antifungal effect was measured by the broth microdilution method and was expressed as the minimal inhibitory concentration (MIC). The MIC value of the granitic powder was ranged from 31.3 to 250mg/ml. Terbinafine showed the lowest MIC value among the 5 commercial antifungal agents $(0.0078-0.125{\mu}g/ml)$, while fluconazole showed the highest MIC values $(125-1,000{\mu}g/ml)$. The MIC range of itraconazole, griseofuvin and ketoconazole were $0.125-0.5{\mu}g/ml\;0.625-5{\mu}g/ml$ and $10-40{\mu}g/ml$ respectively. The Geometric mean(GM) MIC values of terbinafine and ketoconazole against M. canis isolated from human were $0.0078{\mu}g/ml\;and\;10{\mu}g/ml$, respectively, while the GM MIC values of these agents against M. canis isolated from animals were $0.063{\mu}g/ml\;and\;31.4{\mu}g/ml$, respectively. Other antifungal agents did not show any significant differences in antifungal activity against M. canis of animal or human origin. Although granitic powder was shown to have antifungal activity, it was much lower than that of the 5 commercialized antifungal agents.

Keywords

References

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