Journal of the Korean Society of Tobacco Science (한국연초학회지)

The Korean Society of Tobacco Science (한국연초학회)
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Cigarette Smoke Attenuates Histopathological and Neurobiological Changes Caused by 87V Scrapie Agent Infection in IM Mice

  • Sohn Hyung-Ok (KT&G Central Research Institute) ;
  • Hyun Hak-Chul (KT&G Central Research Institute) ;
  • Shin Han-Jae (KT&G Central Research Institute) ;
  • Han Jung-Ho (KT&G Central Research Institute) ;
  • Park Chul-Hoon (KT&G Central Research Institute) ;
  • Moon Ja-Young (Department of Biochemistry and Health Sciences, College of Natural Sciences, Changwon National University) ;
  • Lim Heung-Bin (Department of Tobacco Science, College of Agriculture, Chungbuk National University) ;
  • Kim Yong-Sun (Ilsong Institute of Life Science, Hallym University) ;
  • Lee Dong-Wook (KT&G Central Research Institute)
  • Published : 2005.12.01
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Abstract

Cigarette smoking has been known to have a few beneficial effects on some neuronal diseases such as Alzheimer's disease(AD), Parkinson's disease(PD) and prion disease by scrapie agent shows many similar properties with AD. In this respect, we investigated what biological effects are exerted by cigarette smoke exposure(CSE) in the brain of mouse infected by 87V scrapie. The scrapie agent was inoculated through stereotaxic microinjection of the homogenates of the scrapie agent infected brain into the intracerebral system in the 1M mice. The inoculation into mice typically exhibits neurochemical, physiological and histopathological characteristics of prion disease: loss of neurotransmitters and induction of astrocytosis and vacuolation in brain as well as reduction of spatial movement and loss of body weight. CSE led to alleviated the loss of body weight and also improved spatial movement of the infected mice. Most interestingly, CSE attenuated astrocytosis and vacuolation caused by scrapie infection in the brain. In addition, decreased levels of dopamine in striatal and hypothalamic regions as well as serotonin level in hippocampus caused by scrapie infection were also attenuated by exposure to cigarette smoke. These findings suggest that cigarette smoke, by its inhibition of astrocytosis and vacuolation followed by its restoration of levels of some neurotransmitters, may partly contribute to suppression in the progress of neurodegeneration caused by scrapie infection.

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References

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