Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Effect of Giant Embryonic Rice Supplementation on the Lipid Peroxide Levels and Antioxidative Enzyme Activities in the Plasma and Liver of Streptozotocin-induced Diabetic Rats

거대배아미 식이가 streptozotocin 유도 당뇨 흰쥐의 혈장과 간 조직 중 지질과산화물 농도와 항산화 효소 활성에 미치는 효과

  • Lee, Youn-Ri (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Kang, Mi-Young (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Nam, Seok-Hyun (Department of Biological Science, Ajou University)
  • Published : 2005.12.31
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Abstract

Effects on the feeds of streptozotocin-induced diabetic rats with a giant embryonic rice on lipid peroxides level and antioxidative enzyme activites in plasma and liver tissues were investigated. Along with the experimental periods, all animals in diabetic groups had a lower increase rate in body weight than the normal control group. A giant embryonic rice-fed group showed a inhibition in the decrease of body weight, and a increase in feed intake compared to the normal control group. The organ weights of the diabetic control group were heavier than those of the normal control while rice-fed groups including the giant embryonic rice-fed group were found to have lower organ weights, and its blood sugar level was found to be lower than those of the normal group. Lipid peroxides of the giant embryonic rice-fed animals showed a lower lipid peroxidation values compared to that of the diabetic control group. Plasma vitamin A and E concentrations of the diabetic control group were significantly decreased compared to the normal control while those of the giant embryonic rice-fed group were found to be significantly higher than those of the diabetic control. Of the hepatic antioxidative enzymes, SOD activity of the giant embryonic rice-fed group was higher than that of the diabetic control group. Taken these together, low lipid peroxidation values and, in contrast, high antioxidative enzyme activities were thought to be a cause for decreasing hepatic oxidative damages.

Streptozotocin으로 당뇨를 유발한 쥐에서 거대배아미의 급여가 혈장 및 간조직의 지질과산화물과 항산화효소에 미치는 영향을 조사하였다. 실험기간동안 모든 당뇨군들의 체중증가는 정상군에 비해서는 유의적으로 낮았다. 거대배아미를 급여한 군은 당뇨대조군에 비해서 체중감소현상이 억제되었으며, 식이섭취량은 정상군에 비해 당뇨대조군들이 높게 나타났다. 장기무게는 당뇨군이 당뇨대조군보다 높았으나 거대배아미를 포함한 쌀식이군에서는 낮게 나타났고, 혈당의 변화는 당뇨대조군에 비해서 거대배아미군이 감소하는 경향을 보였다. 혈장 및 간조직 중의 지질과산화물은 당뇨대조군에 비해서 거대배아미가 낮은 수준의 지질과산화물 값을 보였다. 혈장중의 비타민 A와 E의 농도는 당뇨대조군이 정상군에 비해서 유의적으로 감소하였으며 당뇨대조군에 비해 거대배아미급여군이 유의적으로 높게 나타났다. 간조직의 항산화 효소 중 SOD의 활성은 거대배아미군이 당뇨대조군에 비하여 높았다. 이상의 결과에서 거대배아미를 급여한 당뇨쥐의 낮은 지질과산화물값과 높은 항산화계 효소의 활성이 간조직의 산화적 손상을 감소시키는 원인으로 생각된다.

Keywords

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