Applied Biological Chemistry

  • 제48권4호
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  • Pages.326-330
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  • 2005
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  • 2468-0834(pISSN)
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  • 2468-0842(eISSN)
한국응용생명화학회 (The Korean Society for Applied Biological Chemistry)
권호 표지

인공 DNase의 리간드 화합물로써 2,9-(N,N-Dimethylethylenediaminomethyl)-1,10-phenanthroline 분자내 수소결합들의 역할

The Roles of Hydrogen Bonds in 2,9-(N,N-Dimethylethylenediaminomethyl)-1,10-phenanthroline Molecule as a New Ligand Compound of Artificial DNase

  • 성낙도 (충남대학교 농업생명과학대학 응용생물화학부) ;
  • 박경용 (충남대학교 형질전환복제돼지연구센터)
  • Sung, Nack-Do (Division of Applied Biology and Chemistry, College of Agriculture and Life Science, Chungnam National University) ;
  • Park, Kyeng-Yong (Research Center for Transgenic Cloned Pigs, Chungnam National University)
  • 발행 : 2005.12.31
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초록

인공 DNase의 새로운 리간드 분자로 설계된 2,9-(N,N-dimethylethylenediamino)-1,10-phenanthroline(A) 및 2,9-(N,N-Dimethylethylenediaminomethyl)-1,10-phenanthroline(B)의 Cu(II) 착 화합물에 의한 2',3'-cAMP의 촉매 가수분해 반응에서 리간드 분자의 아미노기들과 2',3'-cAMP의 인산기 사이에 형성되는 분자내 4개의 수소결합들로 인하여 (A) 및 (B)의 Cu(II) 착 화합물은 2,9-dimethyl-o-phenanthroline의 Cu(II) 착 화합물에 의한 2',3'-cAMP의 촉매 가수분해 반응 속도를 7만배 이상 빠르게 촉진 할 것으로 예측되었다.

In the catalytic hydrolysis of 2',3'-cAMP by the Cu(II) complexes of 2,9-(N,N-dimethylethylenediamino)-1,10-phenanthroline (A) and 2,9-(N,N-dimethylethylenediaminomethyl)-1,10-phenanthroline (B) that are designed as a new ligand molecule of artificial DNase, due to the four intramolecular H-bonds forming between amino groups of ligand molecule and phosphoryl group of 2',3'-cAMP. It is anticipated that Cu(II) complexes of (A) and (B) are able to promote a rate that is as much as seventy thousand times faster than the catalytic hydrolysis rate of 2',3'-cAMP by Cu(II) complexes of 2,9-dimethyl-o-phenanthroline.

키워드

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