Genomics & Informatics
- Volume 3 Issue 3
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- Pages.86-93
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- 2005
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- 1598-866X(pISSN)
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- 2234-0742(eISSN)
KBUD: The Korea Brain UniGene Database
- Jeon, Yeo-Jin (Laboratory of Human Genomics, Genome Research Center) ;
- Oh, Jung-Hwa (Laboratory of Human Genomics, Genome Research Center) ;
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Yang, Jin-Ok
(National Genome Information Center (NGIC), Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
- Kim, Nam-Soon (Laboratory of Human Genomics, Genome Research Center)
- Published : 2005.09.01
Abstract
Human brain EST data provide important clues for our understanding of the molecular biology associated with the function of the normal brain and the molecular pathophysiology with brain disorders. To systematically and efficiently study the function and disorders of the human brain, 45,773 human brain ESTs were collected from 27 human brain cDNA libraries, which were constructed from normal brains and brain disorders such as brain tumors, Parkinson's disease (PO) and epilepsy. An analysis of 45,773 human brain ESTs using our EST analysis pipeline resulted in 38,396 high-quality ESTs and 35,906 ESTs, which were coalesced into 8,246 unique gene clusters, showing a significant similarity to known genes in the human RefSeq, human mRNAs and UniGene database. In addition, among 8,246 gene clusters, 4,287 genes (