YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Amomum xanthiodes on the Mast Cell-Mediated Allergic Reaction

비만세포 유래의 알레르기 반응에 대한 사인의 효과

  • Published : 2005.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

The discovery of drugs for the treatment of mast cell-mediated allergic disease is a very important subject in human health. The Amomum xanthiodes (Zingiberaceae) has been used for centuries as a traditional medicine in Korea and is known to have an anti-inflammatory effect. However, its specific mechanism of action is still unknown. In this report, we investigated the effect of hot water extract from Amomum xanthiodes (EAX) on the mast cell-mediated allergic reaction and studied its possible mechanisms of action. EAX inhibited compound 48/80-induced systemic anaphylaxis and serum his­tamine release in mice. EAX decreased the passive cutaneous anaphylaxis reaction activated by anti-dinitrophenyl (DNP) IgE antibody. EAX dose-dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. EAX increased cAMP and decreased compound 48/80-induced intracellular $Ca^{2+}$ levels. Our findings provide evidence that EAX inhibits mast cell-derived allergic reactions, and also demonstrate the involvement of cAMP and intracellular $Ca^{2+}$ in these effects.

Keywords

References

  1. Metcalfe, D. D., Kaliner, M. and Donlon, M. A. : The mast cell. Crit. Rev. Immunol. 3, 23 (1981)
  2. Miyajirna, I., Dombrowicz, D., Martin, T. R., Ravetch, J. V., Kinet, J. P. and Galli, S. J. : Systemic anaphylaxis in the mouse can be mediated largely through IgGl and Fe gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgGl-dependent passive anaphylaxis. J. Clin. Invest. 99, 901 (1997) https://doi.org/10.1172/JCI119255
  3. Church, M. K. and Levi-Schaffer, F. : The human mast cell. J. Allergy Clin. Immunol. 99, 155 (1997) https://doi.org/10.1016/S0091-6749(97)70089-7
  4. Peterson, L. J., Mosbech, H. and Skov, P. S. : Allergen-induced histamine release in intact human skin in vivo assessed by skin microdialysis technique: characterization of factors influencing histamine releasability. J. Allergy Clin. Immunol. 97, 672 (1996) https://doi.org/10.1016/S0091-6749(96)70313-5
  5. Ennis, M., Pearce, F. L. and Weston, P. M. : Some studies on the release of histamine from mast cells stimulated with polylysine. Br. J. Pharmacol. 70, 329 (1980) https://doi.org/10.1111/j.1476-5381.1980.tb07940.x
  6. Alfonso, A., Cabado, A. G., Vieytes, M. R. and Botana, L. M. : Functional compartments in rat mast cells for cAMP and calcium on histamine release. Cell Signal. 12, 343 (2000) https://doi.org/10.1016/S0898-6568(00)00070-X
  7. Beaven, M. A., Rogers, J., Moore, J. P., Hesketh, T. R., Smith, G. A. and Metcalfe, J. C. : The mechanism of the calcium signal and correlation with histamine release in 2H3 cells. J. BioI. Chem. 259, 7129 (1984)
  8. Beaven, M. A. and Metzger, H. : Signal transduction by Fe receptors: the Fe epsilon RI case. Immunol. Today 14, 222 (1993) https://doi.org/10.1016/0167-5699(93)90167-J
  9. Alm, P. E. : Modulation of mast cell cAMP levels. A regulatory function of calmodulin. Int. Arch. Allergy APPI. Immunol. 75, 375 (1984) https://doi.org/10.1159/000233650
  10. Botana, L. M. and MacGlashan, D. W. : Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils. J. Leukoc. Biol. 55, 798 (1994) https://doi.org/10.1002/jlb.55.6.798
  11. Ou, M. : Chinese-English manual of common-used in traditional chinese medicine. Hong Kong: Joint Publishing, 154 (1992)
  12. Kitajima, J. and Ishikawa, T. : Water-soluble constituents of amomum seed. Chem. Pharm. Bull. (Tokyo) 51, 890 (2003) https://doi.org/10.1248/cpb.51.890
  13. Kwon, K. B., Kim, J. H., Lee, Y. R., Lee, H. Y., Jeong, Y. J., Rho, H. W., Ryu, D. G., Park, J. W. and Park, B. H. : Amomum xanthoides extract prevents cytokine-induced cell death of RINm5F cells through the inhibition of nitric oxide formation. Life Sci. 73, 181 (2003) https://doi.org/10.1016/S0024-3205(03)00267-4
  14. Kim, S. H., Choi, C. H., Kim, S. Y., Eun, J. S. and Shin, T. Y. : Anti-allergic effects of Artemisia iwayomogi on mast cell-mediated allergy model. Exp. BioI. Med. (Maywood) 230, 82 (2005) https://doi.org/10.1177/153537020523000111
  15. Shore, P. A., Burkhalter, A. and Cohn, V. H. Jr. : A method for the fluorometric assay of histamine in tissues. J. Pharmacol. Exp. Ther. 127, 182 (1959)
  16. Peachell, P. T., MacGlashan, D. W. Jr., Lichtenstein, L. M. and Schleimer, R. P. : Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate. J. Immunol. 140, 571 (1988)
  17. Kemp, S. F. and Lockey, R. F. : Anaphylaxis: a review of causes and mechanisms. J. Allergy Clin. Immunol. 110, 341 (2002) https://doi.org/10.1067/mai.2002.126811
  18. Mousli, M., Bronner, C., Bockaert, J., Rouot, B. and Landry, Y. : Interaction of substance P, compound 48/80 and mastoparan with the alpha-subunit C-terminus of G protein. Immunol. Lett. 25, 355 (1990) https://doi.org/10.1016/0165-2478(90)90207-7
  19. Chahdi, A., Fraundorfer, P. F. and Beaven, M. A. : Compound 48/80 activates mast cell phospholipase D via heterotrimeric GTP-binding proteins. J. Pharmacol. Exp. Ther. 292, 122 (2000)
  20. Kaliner, M. and Austen, K. F. : Cyclic AMP, ATP, and reversed anaphylactic histamine release from rat mast cells. J. Immunol. 112, 664 (1974)
  21. Tasaka, K., Mio, M. and Okamoto, M. ; Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann. Allergy 56, 464 (1986)
  22. Weston, M. C. and Peachell, P. T. ; Regulation of human mast cell and basophil function by cAMP. Gen. Pharmacol. 31, 715 (1998) https://doi.org/10.1016/S0306-3623(98)00080-9
  23. Seo, S. B., Park, S. J., Park, S. K., Cho, C. C., Park, B. H., Lee, S. J., Kim, H. M., Kajiuchi, T. and Shin, T. Y. : Disodium cromoglycate inhibits production of immunoglobulin E. Immunopharmacol. Immunotoxicol. 23, 229 (2001) https://doi.org/10.1081/IPH-100102562
  24. 김숙현, 김대근, 임종필, 채병숙, 신태용 : Inhibitory effect of Lycopus lucidus on mast cell-mediated immediated-type allergic reactions. 약학회지 46, 405 (2002)