Biomedical Science Letters (대한의생명과학회지)
- Volume 11 Issue 3
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- Pages.407-416
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- 2005
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Clinical Effects of Preoperative treated-Methylprednisolone in Pediatric Cardiac Surgery with Cardiopulmonary Bypass
- Choi Seok-Cheol (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
- Kim Yang-Weon (Department of Emergency Medicine, Busan Paik Hospital, College of Medicine, Inje University) ;
- Jang Jung Hoon (Head of Epidemiology/Biostatistics Team, Regional Clinical Trial Center, Busan Paik Hospital, Inje University)
- Published : 2005.09.01
Abstract
Cardiopulmonary bypass (CPB) for cardiac surgery induces the production and release of numerous chemotactic substances and cytokines, ensuing systemic inflammatory response that causes postoperative major organ dysfunctions. We performed a randomized, prospective study to investigate clinical effects of preoperative treated-methylprednisolone for preventing inflammation in pediatric cardiac surgery with CPB. Thirty pediatric patients scheduled for elective cardiac surgery were randomized to either control(n=15) or steroid group (n=15, 10 mg/kg of methylprednisolone). Arterial blood samples were taken before and after the operations for measuring total leukocyte (T-WBC) and differential counts, platelet counts, interleukin-6 (IL-6), myeloperoxidase (MPO), neuron specific enolase (NSE), troponin-I (TNI), aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine levels. Postoperative parameters such as pulmonary index (PI,