Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Treatment Effect of Mulberry Root-Bark (Mori radicis Cortex) Extract on Hypercholesterolemia in Rabbits

  • Kim Dong Kyu (College of Veterinary Medicine and Research institute of Veterinary Medicine, Chungbuk National University) ;
  • Chai Hee-Youl (College of Veterinary Medicine and Research institute of Veterinary Medicine, Chungbuk National University) ;
  • Kim Tae Myung (College of Veterinary Medicine and Research institute of Veterinary Medicine, Chungbuk National University) ;
  • Lee Nam-Jin (College of Veterinary Medicine and Research institute of Veterinary Medicine, Chungbuk National University) ;
  • Cho Jung-Hee (College of Veterinary Medicine and Research institute of Veterinary Medicine, Chungbuk National University) ;
  • Park Jung-Hui (Park, Jung-Hui Oriental Medical Clinic,) ;
  • Kang Jong-Koo (College of Veterinary Medicine and Research institute of Veterinary Medicine, Chungbuk National University) ;
  • Kim Yun-Bae (Department of Clinical Laboratory Medicine, Chungbuk National University Hospital) ;
  • Hwang Seock-Yeon (Department of Clinical Laboratory Medicine, Chungbuk National University Hospital)
  • Published : 2005.09.01
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Abstract

This study reports that the effect of Mori radicis cortex, Mulberry root-bark, on the lipid peroxidation products formation in the liver, blood serum and atherosclerosis of hypercholesterolemia rabbits fed Mulberry root-bark for eight weeks. The rabbits were permitted a fixed quantity to extract of Mulberry root-bark mixed hypercholesterol fodder. The lipid peroxidation products, malondialdehyde (MDA) was significantly diminished. Total cholesterol in serum worthily decreased. Also, triglyceride and high density lipoproteins (HDLs) increased after feeding Mori radicis cortex. Besides, thicky atheromatous plaque on the wall of aorta of rabbits fed on hypercholesterol diet were markedly attenuated by Mulberry root-bark extract. These results support and substantiate the extract of Mulberry root-bark as protection against lipid peroxidation in the liver, blood serum and atherosclerosis.

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