Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)
- Volume 15 Issue 5
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- Pages.606-612
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- 2005
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- 1225-6781(pISSN)
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- 2288-8802(eISSN)
Study on Oriental Prescription for Medicinal Food Applications -Effects and Mechanism of Saengmaegsan on the Relaxation of Contracted Artery and Regional Cerebral Blood Flow-
한약처방을 활용한 Medicinal Food의 개발에 관한 연구 - 생맥산이 수축동맥의 이완과 국소뇌혈류량에 미치는 효과 및 기전 -
- Park Sung-Hye (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
- Kim Woon-Ju (Dept. of Food & Nutrition, Home Ecology, Chungbuk National University)
- Published : 2005.10.01
Abstract
This study was performed to provide basic data that predict the application of Saengmaegsan(SMS) as medicinal food. SMS has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. We examined the effects of SMS on physiological function in isolated abdominal aorta and femoral artery from rabbit and measured the changes of regional cerebral hood flow(rCBF), which was continually monitored by laser-doppler flowmeter and pressure transducer in anesthetized adult Spargue-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. The contraction forces by injection of norephinephrine in isolated abdominal aorta and femoral artery were significantly decreased in each concentration of SMS treatment compared with control. rCBF was increased by SMS in a dose-dependent manner. These results suggest that SMS causes a diverse response of rCBF and arterial diameter. These mechanism in rCBF increase may be mediated by prostaglandis, cyclic GMP and adrenergic
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