Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Kitasatospora sp. MJM383 Strain Producing Two Antitumor Agents, Streptonigrin and Oxopropaline G

  • JIN YING-YU (Institute of Bioscience and Biotechnology, Department of Biological Science, Myong Ji University) ;
  • YOON TAE-MI (Institute of Bioscience and Biotechnology, Department of Biological Science, Myong Ji University, Extract Collection of Useful Microorganism (ECUM), Myong Ji University) ;
  • KIM WON-KON (Korean Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • KIM KYOUNG-ROK (Institute of Bioscience and Biotechnology, Department of Biological Science, Myong Ji University, Extract Collection of Useful Microorganism (ECUM), Myong Ji University) ;
  • SONG JEA-KYOUNG (Korean Agricultural Culture Collection (KACC), Genetic Resources Division, National Institute of Agricultural Biotechnology) ;
  • KIM JONG-GWAN (Extract Collection of Useful Microorganism (ECUM), Myong Ji University) ;
  • LIU JING (Institute of Bioscience and Biotechnology, Department of Biological Science, Myong Ji University) ;
  • YANG YOUNG-YELL (Institute of Bioscience and Biotechnology, Department of Biological Science, Myong Ji University) ;
  • KWON HYUNG-JIN (Institute of Bioscience and Biotechnology, Department of Biological Science, Myong Ji University) ;
  • SUH JOO-WON (Institute of Bioscience and Biotechnology, Department of Biological Science, Myong Ji University, Extract Collection of Useful Microorganism (ECUM), Myong Ji University)
  • Published : 2005.10.01
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Abstract

MJM383, a rare actinomycete sp. strain originated from Chinese soils, was isolated through an antimicrobial screening system. The analysis of 16S rDNA sequences and biochemical characterization determined the strain to belong to genus Kitasatospora. Both NMR and ESI mass data of its purified bioactive compounds revealed Kitasatospora sp. MJM383 to produce two antitumor agents, streptonigrin and oxopropaline G, which have been known to be produced from Streptomyces species. This is the first report to demonstrate the presence of antitumor agents produced by genus Kitasatospora.

Keywords

References

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