Screening of Plants in Jeju for Whitening Materials in Cosmeceutical

제주산 식물을 이용한 미백 기능성화장품 원료에 대한 검색

  • Lee, Sun-Joo (Department of Chemistry, Cheju National University) ;
  • Bu, Hee-Jung (Department of Chemistry, Cheju National University) ;
  • Lee, Jung-A (Department of Chemistry, Cheju National University) ;
  • Jung, Duk-Sang (Department of Chemistry, Cheju National University)
  • 이선주 (제주대학교 자연과학대학 화학과) ;
  • 부희정 (제주대학교 자연과학대학 화학과) ;
  • 이정아 (제주대학교 자연과학대학 화학과) ;
  • 정덕상 (제주대학교 자연과학대학 화학과)
  • Published : 2005.03.01

Abstract

Methanol extract of plants in Jeju were investigated for biological properties related to whitening cosmeceuticals such as melanin contents on melanoma cell, mushroom tyrosinase activity inhibition. We found that extracts of leaves of Hypochoeris radicata, Solanum nigrum, Solidago serotica Gynostenmma pentaphyllum and Taxus cuspidata inhibit melanin synthesis in B16F10 melanoma cells. However they have no tyrosinase inhibitory activity.

제주에서 자생하는 식물들의 미백활성을 B16F10 세포에서의 멜라닌 생성 억제, mushroom tyrosinase 활성 억제 실험을 통하여 확인하였다. 본 실험에서 우리는 개민들레 줄기, 까마중, 미국미역취, 돌외, 주목의 메탄을 추출물에서 B16F10 세포에서의 멜라닌 생성 저해 효과를 확인하였다. 그러나 이들의 tyrosinase 활성은 없었다.

Keywords

References

  1. 이현호, 최근 미백화장품의 개발동향, J. Soc. Cosmet. Scientists Korea, 23, 43 (1997)
  2. V. J. Hearing and T. M. Ekel, Mammalian tyrosinase, Biochem. J., 157, 549 (1976) https://doi.org/10.1042/bj1570549
  3. Y. Mishima, S. Hatta, and Y. Ohyama, Induction of melanogenesis suppression: cellular pharmacology and mode of differential action, Pigment Cell Res., 1, 367 (1998) https://doi.org/10.1111/j.1600-0749.1988.tb00136.x
  4. H. Matubara, Inhibitory effect of lichen metabolites and their synthetic analogues on melanin biosynthesis in cultured B-16 mouse melanoma cells, Natural Product Scienses, 4, 3 (1998)
  5. S. Ando, O. Ando, Y. Suemoto, and Y. Mishima, Tyrosinase gene transcription and its control by melanogenic inhibitor, J. Invest. Dermatol., 100, 15 (1993) https://doi.org/10.1111/1523-1747.ep12349870
  6. G. Imokawa and Y. Mishima, Loss of melanogenic properties in tyrosinase induced by glycosilation inhibitors within malignant melanoma, Cancer Res., 42, 1994 (1982)
  7. M. Masuda, T. Tejirna, and T. Suzuki, Skin lighteners, Cosmetics & Toiletries, 111, 65 (1996)
  8. T. Mosmann, Rapid colorimetric assay for the cellular growth and survival application to proliferation and cytotoxic assay J. Immun Methods, 65, 55 (1983) https://doi.org/10.1016/0022-1759(83)90303-4
  9. K. Meada and M. Fukuda, In vitro effectiveness of whitening cosmetic components in human melanocyte. J. Soc. Cosmet. Chem, 42, 361 (1991)
  10. P. R. Gordon, C. P. Mansur, and B. A, Gilchrest, Regulation of human melanocyte growth, dendricity, and melanization by keratinicyte derived factors. J. Invest. Dermatol., 2, 566 (1989)