Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Mast Cell Distribution at Predilection Sites of Atopic Dermatitis in Normal Canine Skin

개의 아토피성 피부염의 피부증상 호발부위의 비만세포분포조사

  • Yi Seong-Joon (Department of Veterinary Anatomy, College of Veterinary Medicine, Kyungpook National University) ;
  • Jeong A-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Oh Tae-Ho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
  • 이성준 (경북대학교 수의과대학 해부학교실) ;
  • 정아영 (경북대학교 수의과대학 내과학교실) ;
  • 오태호 (경북대학교 수의과대학 내과학교실)
  • Published : 2005.09.01
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Abstract

Mast cell distribution was quantified in acidified toluidine blue sections of normal skin from 8 different sites in 10 dogs and compared to the predilection sites of canine atopic dermatitis. Mast cell counts varied significantly from site to site (p<0.0001) and counts in the superficial dennis were significantly higher than the deeper dennis (p<0.05). The highest mast cells distribution sites were the concave surface of the ear (mean $74.88{\pm}17.93\;per\;mm^{2}$) and the interdigital skin of the forefeet (mean $28.326{\pm}6.24\;per\;mm^{2}$). Counts in these sites were $280\%$ higher than all the other sites. Our results may provide some evidence that cutaneous mast cell distribution may be a factor in the frequent occurrence of ear and foot pruritus in atopic dermatitis. However, the low mast cell count in the predilection sites of atopic dermatitis did not explain the common occurrence of atopic lesions. Therefore, other factors or more complicated pathogenesis may be correlated with these predilection sites.

개의 아토피성 피부염의 피부증상이 호발하는 8부위에서 비만세포의 분포를 조사 비교하였다. 피부증상을 보이지 않는 10두의 개의 8부위의 피부조직을 채취하여 비만세포에서 특이적인 acidfied toluidine blue 염색을 하여 현미 경하에서 계수비교하였다. 비만세포수는 표재진피에서 각각의 부위간에 유의한 변화가 관찰되었으며 (p<0.0001) 표재진피가 심재진피에 비해 유의하게 높았다 (p<0.05). 호발 부위중 비만세포가 가장 높은 부위는 내측이개와 지간으로 각각 $74.88{\pm}17.93\;per\;mm^2$, $28.33{\pm}6.24\;per\;mm^2$이었다. 이 부위는 다른 부위에 비해 비만세포가 $280{\%}$ 높게 분포하였다. 따라서 개의 아토피성 피부염의 호발증상인 귀와 발의 소양증의 발생은 비만세포의 수가 다른 부위에 비해 높은 것이 하나의 요인으로 사료된다. 그러나 비만세포의 수가 낮게 나타난 다른 호발부위에 대해서는 다른 요인이 관계하는 것으로 사료되며 이에 관한 연구가 필요하다.

Keywords

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