A study on trend of residual changes in blood and eggs of laying hens after oral administration of quinolones

산란계에서 퀴놀론계 약물투여 후 혈장 및 계란내의 잔류함량 변화추이 조사

  • Sim Ea-Ran (Ulsan Metropolitan Health & Environment Research Institute) ;
  • Kim Mi-Hee (Ulsan Metropolitan Health & Environment Research Institute) ;
  • Yoo Eun-Ah (Ulsan Metropolitan Health & Environment Research Institute) ;
  • Lee Yun-Jung (Ulsan Metropolitan Health & Environment Research Institute) ;
  • Chun Soon-Yong (Ulsan Metropolitan Health & Environment Research Institute) ;
  • Moon Soo-Pyeong (Ulsan Metropolitan Health & Environment Research Institute) ;
  • Hahm Yoo-Sik (Ulsan Metropolitan Health & Environment Research Institute)
  • 심애란 (울산광역시보건환경연구원) ;
  • 김미희 (울산광역시보건환경연구원) ;
  • 유은아 (울산광역시보건환경연구원) ;
  • 이윤정 (울산광역시보건환경연구원) ;
  • 천순용 (울산광역시보건환경연구원) ;
  • 문수평 (울산광역시보건환경연구원) ;
  • 함유식 (울산광역시보건환경연구원)
  • Published : 2005.09.01

Abstract

The purposes of this study were to evaluate the distribution of quinolone and to investigate the effects of quinolones (enrofloxacin, ciprofloxacin) in blood(plasma) and eggs of laying hens. Animals were fed quinolones which supplemented with 20, 50, 80 mg/kg of body weight. Blood and egg samples were collected after oral administration and analyzed for quinolones (enrofloxacin, ciprofloxacin) by HPLC. In laying hens, the residue period of enrofloxacin were longer than that of ciprofloxacin and the levels of residues were elavated by drug dosage.

Keywords

References

  1. Gigosos PG, Revesado PR, Cadahia O, et al. 2000. Determination of quinolones in animal tissues and eggs by high- perfermance liquid chromatography with photodiiode-array detection. J Chromathpgr A 871 : 31-36 https://doi.org/10.1016/S0021-9673(99)01048-1
  2. Herikstad H, Fracaro Ml. 1997. Emerging quinolonr-resistant Salmonella in the United States. Emerging Infect Dis 3 : 253-372 https://doi.org/10.3201/eid0303.970301
  3. Anadon A, Martinez-Larranaga MR, Iturbe J, et al. 2001. Pharmacokinetics and residues of ciprofloxacin and its metabolites in broiler chickens. Res Vet Sci 71 : 101-109 https://doi.org/10.1053/rvsc.2001.0494
  4. Rohwedder R, Bergan T, Caruso E, et al. 1991. Penetration of ciprofloxacin and its metabolite into lung, bronchial and pleural tissue after 250 and 500mg PO ciprofloxacin, Chemotherapy 37 : 229-238 https://doi.org/10.1159/000238860
  5. Intorre L, Cecchini S, Bertii S, et al. 2000. Pharmacokinetics of enrofloxacin in the sea bath(Dicentrarchus labrax). Aquaculture 182 : 49-59 https://doi.org/10.1016/S0044-8486(99)00253-7
  6. Anadon A, Martinez-Larranaga MR, Diaz MJ, et al. 1995. Pharmacokinetics and residues of enrofloxacin in cickens. Am J Vet Res 56(4) : 501-506
  7. Son SW. 1999. Studies on the detection of quinolones in foods of animal origin. Dissertation for doctor of philosophy, Seoul National University : 66-99
  8. Suren G, Hammer P, Heeschem W. 1996. Detection of residues of quinolones in milk. In proceedings of the EuroResidue III conferece on residues of veterinary drugs in food, Veldhoven, The Netherlands 6-8 : 917-921
  9. Donoghue DJ, Schneider MJ. 2003. Comparison between a bioassay and liquid chromatography-fluorescence-mass spectrometry(n) for the determination of incurred enrofloxacin in whole eggs. J AOAC Int 86(4) : 669-674
  10. Gorla N, Chiostri E, Ugnia L, et al. 1997. HPLC residues of enrofloxacin and ciprofloxacin in eggs of laying hens. Int J Antimicrob Agents 8 : 253-256 https://doi.org/10.1016/S0924-8579(97)00018-6