Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibitory Effect of Methanolic Extract of Cnidii Rhizoma on the Melanogenesis

천궁 메탄올 추출액의 멜라닌 형성 억제 효과

  • Park, Jong-Hun (College of Oriental Medicine, Sangji University) ;
  • Kim, Yang-Jin (College of Oriental Medicine, Sangji University) ;
  • Mun, Yeun-Ja (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Young-Cheol (College of Oriental Medicine, Sangji University) ;
  • Woo, Won-Hong (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 박종훈 (상지대학교 한의과대학) ;
  • 김양진 (상지대학교 한의과대학) ;
  • 문연자 (원광대학교 한의학전문대학원) ;
  • 이영철 (상지대학교 한의과대학) ;
  • 우원홍 (원광대학교 한의학전문대학원)
  • Published : 2005.08.01
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Abstract

Down-regulation of melanin synthesis is required for recovery of pigmentary disorders and it is known that direct inhibitors of tyrosinase suppress melanin synthesis. We screened several oriental medicinal plants using B16/Fl0 cells and found that the methanolic extract of Cnidii Rhizoma down-regulated melanin synthesis effectively. Although the proliferation of Bl6/Fl0 cells was decresed by the methanolic extract of Cnidii Rhizoma, it did not appear necrosis. Bl6/F10 cells incubated with the methanolic extract of Cnidii Rhizoma showed reduced pigmentation and tyrosinase activity. Western blotting revealed that the amount of tyrosinase was decreased by the methanolic extract of Cnidii Rhizoma. These results suggest that the inhibitary effect of the methanolic extract of Cnidii Rhizoma on melanogenesis is due to the suppression of tyrosinase in Bl6/F10 cells and Cnidii Rhizoma is a candidate for an efficient whitening agent.

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References

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