Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Immunomodulatory Effect of Bio-Q, Bokiikhyul Prescription

보기익혈 복합방, 바이오 큐의 면역조절 효과

  • Lee, Hyo-Jung (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Khil, Jae-Ho (Department of Sports Medicine, Kyunghee University) ;
  • Baek, Nam-In (School of Biotechnology and Plant Metabolism Research Center, Kyunghee University) ;
  • Ra, Jeong-Chan (RNL Co.) ;
  • Kim, Sung-Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
  • 이효정 (경희대학교 동서의학 대학원) ;
  • 길재호 (경희대학교 체육대학 스포츠의학과) ;
  • 백남인 (경희대학교 생명과학대학) ;
  • 라정찬 (RNL 생명과학㈜) ;
  • 김성훈 (경희대학교 동서의학 대학원)
  • Published : 2005.08.01
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Abstract

Bio-Q is a modified prescription with the activities of supplementing Qi and blood in human body. In the present study, immunomodulatory effect of Bio-Q was examined. After oral administration of Bio-Q for 7 days to Balb/c mice, splenocytes were isolated and immunological experiments were performed. Bio-Q significantly increased the proliferation of splenocytes exposed to concanavalin A (Con A), while it did not in case of lipopolysaccharide (LPS) stimulation. Bio-Q also significantly increased CD3/CD19, CD4/CDB and NK cells by flow cytometric analysis. In addition, Bio-Q significantly enhanced the level of $INF-\gamma$ in splenocytes, but not $TNF-\alpha$ by ELISA. These results strongly suggest that Bio-Q has immunomodulatory activity through the regulation of T cell mediated immune pathway.

Keywords

References

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