Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Antidiabetic Stilbene and Anthraquinone Derivatives from Rheum undulatum

  • Choi Sang Zin (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University) ;
  • Lee Sung Ok (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University) ;
  • Jang Ki Uk (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University) ;
  • Chung Sung Hyun (Pharmacology Lab, College of Pharmacy, Kyung Hee University) ;
  • Park Sang Hyun (Pharmacology Lab, College of Pharmacy, Kyung Hee University) ;
  • Kang Hee Chol (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology) ;
  • Yang Eun Young (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology) ;
  • Cho Hi Jae (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology) ;
  • Lee Kang Ro (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University)
  • Published : 2005.09.01
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Abstract

The antidiabetic-activity-guided fractionation and isolation of the $80\%$ EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of one stilbene, desoxyrhapontigenin(1) and two anthraquinones, emodin (2) and chrysophanol (3). Their structures were established by chemical and spectroscopic methods. Compounds 1, 2, and 3 inhibited postprandial hyperglycemia by 35.8, 29.5, $42.3\%$, respectively.

Keywords

References

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