Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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A New Furofuran Lignan with Antioxidant and Antiseizure Activities from the Leaves of Petasites japonicus

  • Min Byung-Sun (College of Pharmacy, Catholic University of Daegu) ;
  • Cui Hui Song (College of Pharmacy, Chungnam National University) ;
  • Lee Hyeong-Kyu (College of Pharmacy, Catholic University of Daegu) ;
  • Sok Dai-Eun (College of Pharmacy, Chungnam National University) ;
  • Kim Mee Ree (Department of Food Science and Nutrition, Chungnam National University)
  • Published : 2005.09.01
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Abstract

A new furofuran lignan (1) was isolated from the n-butanol fraction of the methanolic extract of the leaves of Petasites japonicus (Sieb. et Zucc.) Maxim. (Compositae). The structure of compound 1 was determined to be $2{\alpha}-(4'-hydroxy-3'-methoxyphenyl)-6{\alpha}-(4"-hydroxy-3"-methox­yphenyl)-8{\alpha}-hydroxy-3, 7-dioxabicyclo[3.3.0]octane\;4'-O-({\beta}-D-glucopyranoside)$ by spectroscopic methods including 2D-NMR. In further studies, it was found that the compound 1 expressed an antioxidant activity in DPPH radical scavenging assay, and moreover, ameliorated the seizure in kainic acid-treated mice.

Keywords

References

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