Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Prevention of Arthritic Inflammation Using an Oriental Herbal Combination BDX-1 Isolated from Achyranthes bidentata and Atractylodes japonica

  • Han Sang-Bae (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Lee Chang Woo (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Yoon Yeo Dae (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Lee Jong-Ho (BIORADIX Co., Ltd) ;
  • Kang Jong Soon (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Lee Ki Hoon (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Yoon Won Kee (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Lee Kiho (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Park Song-Kyu (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Kim Hwan Mook (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
  • Published : 2005.08.01
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Abstract

An oriental herbal combination (BDX-1) was isolated from Achyranthes bidentata and Atractylodes japonica. We previously tested the clinical effectiveness of BDX-1 in rheumatoid arthritis (RA) patients and found that it has a beneficial therapeutic effect. Here, we provide experimental evidence for the effectiveness of BDX-1 on RA in murine models. The oral administration of BDX-1 was found to markedly inhibit collagen-induced arthritis, adjuvant-induced arthritis, and zymosan-induced inflammation. It also inhibited carrageenan-induced acute edema and acetic acid-induced writhing response. In addition, the biological activity of BDX-1 was found to be strongly increased by fermentation. Our results suggest that BDX-1 could be useful for the treatment of rheumatoid arthritis.

Keywords

References

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