Nutritional Sciences

The Korean Nutrition Society (한국영양학회)
권호 표지

Effects of Pinitol Supplementation and Strength Training on Anaerobic Performance and Status of Energy Substrates in Healthy Young Men

  • Lee, Dae-Taek (Kim Chang Kew Exercise Physiology Laboratory, Kookmin University) ;
  • Lee, Woon-Yong (School of Sports, Health and Management, Woosong University)
  • Published : 2005.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

To assess the effect of pinitol supplementation and strength training for two weeks on the anaerobic capacity during and after exercise, and improvement of glucose metabolism during the recovery period of muscular fatigue with repeated acute bouts of cycling exercise, a total of 24 healthy young men were recruited and randomly and equally divided into three groups; pinitol supplementation group (PSG), placebo group (PLG), and control group (CON). Using a randomized double-blinded design, subjects in PSG were provided pinitol supplement, consumed orally 1.2 g/day, and participated in the resistance exercise program and cycling exercise for two weeks. Subjects in PLG underwent the same protocol as those in PSG but consumed the same amount of placebo. No supplementation and exercise program was given to CON. Before and after the intervention, all subjects were tested for their anaerobic capacities evaluated by Wingate test twice separated by 30 min. During the test, peak anaerobic power (PP), mean anaerobic power, total work, and fatigue index were evaluated During resting and recovery, blood samples were drawn and plasma pinitol, myo-inositol, chiro-inositol, insulin, free fatty acid, glucose, and lactate levels were analyzed After two weeks, PP and relative PP of the second biking were improved from the first biking in PSG only (p<0.05). No changes were found in all other variables of Wingate test in all groups. No statistical differences between groups and pre- and post-intervention were observed in concentrations of pinitol, myo-inositol, and chiro-inositol, but pinitol concentration was higher during recovery compared to the baseline in all groups and testings (p<0.05). Lactate level during recovery was higher than the resting level, but no other blood parameters were significantly changed. In conclusion, two weeks of pinitol supplementation in conjunction with short duration of anaerobic training in healthy young men did not induce any obvious benefits in terms of anaerobic capacity and energy metabolism Individual and/or population susceptibility may be one factor responsible for adopting pinitol supplementation.

Keywords

References

  1. Asplin I, Galasko G, Lamer J. chiro-Inositol deficiency and insulin resistance:a comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects. Proc Natl Acad Sci USA 90:5924-5928, 1993
  2. Holman GD, Kasuga M. From receptor to transporter:insulin signalling to glucose transport. Diabetologia 40:991-1003, 1997 https://doi.org/10.1007/s001250050780
  3. Bates SH, Jones RB, Bailey CJ. Insulin-like effect of pinitol. Br J Pharmacal 130:1944-1948, 2000 https://doi.org/10.1038/sj.bjp.0703523
  4. Fonteles MC, Huang LC, Larner J. Infusion of pH 2.0 D-chiro-inositol glycan insulin putative mediator normalizes plasma glucose in streptozotocin diabetic rats at a dose equivalent to insulin without inducing hypoglycaemia. Diabetologia 39:731-734, 1996 https://doi.org/10.1007/BF00418546
  5. Huang LC, Fonteles MC, Houston DB, Zhang C, Larner L. Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo. Endocrinology 132:652-657, 1993 https://doi.org/10.1210/en.132.2.652
  6. Ortmeyer HK, Larner J, Hansen BC. Effects of D-chiroinositol added to a meal on plasma glucose and insulin in hyperinsulinemic rhesus monkeys. Obes Res 3:605S-608S, 1995 https://doi.org/10.1002/j.1550-8528.1995.tb00196.x
  7. Ortmeyer HK, Huang LC, Zhang L, Hansen BC, Larner J. Chiroinositol deficiency and insulin resistance. II. Acute effects of D-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistant rhesus monkeys. Endocrinology 132:646-651, 1993 https://doi.org/10.1210/en.132.2.646
  8. Phillips DV, Dougherty DE, Smith AE. Cyclitols in soybean. J Agric Food Chem 30:456-458, 1982 https://doi.org/10.1021/jf00111a011
  9. Wojtaszewski JFP, Nielsen JN, Richter EA. Exercise effects on muscle insulin signaling and action, Invited Review:Effect of acute exercise on insulin signaling and action in humans. J Appl Physiol 93:384-392, 2002
  10. Bergstrom J, Hermansen L, Hultman E, Saltin B. Diet, muscle glycogen and physicl performance. Acta Physiol Scand 71:140-150, 1967 https://doi.org/10.1111/j.1748-1716.1967.tb03720.x
  11. Holloszy JO, Kohrt WM, Hansen PA. The regulation of carbohydrate and fat metabolism during and after exercise. Front Biosci 3:D1011-D1027, 1998
  12. Devlin J, Barlow J, Horton E. Whole body and regional fuel metabolism during early postexercise recovery. Am J Physiol Endocrinol Metab 256:E167-E172, 1989
  13. Kjaer M, Farrell P, Christensen N, Galbo H. Increased epinephrine response and inaccurate glucoregulation in exercising athletes. J Appl Physiol 61:1693-1700, 1986
  14. AspS, Daugaard JR, Kristiansen S, Kiens B, Richter EA. Eccentric exercise decreases maximal insulin action in humans:muscle and systemic effects. J Physiol 494:891-898, 1996
  15. Tuominen JA, Ebeling P, Bourey R, Koranyi L, Lamminen A, Rapola J, Sane T, Vuorinen-Markkola H, Koivisto VA. Postmarathon paradox:insulin resistance in the face of glycogen depletion. Am J Physiol Endocrinol Metab 270:E336-E343, 1996
  16. Hayashi T, Wojtaszewski JF, Goodyear LJ. Exercise regulation of glucose transport in skeletal muscle. Am J Physiol Endocrinol Metab 273:E1039-E1051, 1997
  17. Adams GM. Exercise Physiology Laboratory Manual. 3rd ed. pp.88, McGraw Hill Co.. Columbus, OH, 1998
  18. Davis A, Christiansen M, Horowitz JF, Klein S, Hellerstein MK, Ostlund RE Jr.. Effect of pinitol treatment on insulin action in subjects with insulin resistance. Diabetes Care 23:1000-1005, 2000 https://doi.org/10.2337/diacare.23.7.1000
  19. Zierler K. Whole body glucose metabolism. Am J Physiol 276:E409-426, 1999
  20. Campbell WW, Haub MD, Fluckey JD, Ostlund RE Jr., Thyfault JP, Morse-Carrithers H, Hulver MW, Birge ZK. Pinitol supplementation does not affect insulin-mediated glucose metabolism and muscle insulin receptor content and phosphorylation in older humans. J Nutr 134:2998-3003, 2004
  21. Kim JI, Kim JC, Kang MJ, Lee MS, Kim JJ, Cha IJ. Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus:a randomized controlled study. Eur J Clin Nutr 59:456-458, 2005
  22. Campbell WW, Joseph LJO, Ostlund RE Jr., Anderson RA, Farrell PA, Evans WJ. Resistive training and chromium picolinate:Effects on inositols and liver and kidney functions in older adults. Int J Sport Nutr Exerc Metab 14:430-442, 2004
  23. Joseph LJO, Farrell PA, Davey SL, Evans WJ, Campbell WW. Effect of resistance training with or without chromium picolinate supplementation on glucose metabolism in older men and women. Metabolism 48:546-553, 1999 https://doi.org/10.1016/S0026-0495(99)90048-3