Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
권호 표지

Combined Large Cell Neuroendocrine Carcinoma with Component of Adenocarcinoma-A case report-

선암종의 요소를 갖느느 혼압대세포신경내분비암종-1예 보고-

  • Park Jong Un (Department of Thoracic and Cardiovascula Surgery, College of Medicine, Hallym University) ;
  • Lee Jae Woong (Department of Thoracic and Cardiovascula Surgery, College of Medicine, Hallym University) ;
  • Jo Tae Jun (Department of Thoracic and Cardiovascula Surgery, College of Medicine, Hallym University) ;
  • Kim Kun Il (Department of Thoracic and Cardiovascula Surgery, College of Medicine, Hallym University) ;
  • Lee Weon Yong (Department of Thoracic and Cardiovascula Surgery, College of Medicine, Hallym University) ;
  • Hong Ki Woo (Department of Thoracic and Cardiovascula Surgery, College of Medicine, Hallym University) ;
  • Eom Kwang Seok (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Jun Sun-Young (Department of Pathology, College of Medicine, Hallym University)
  • 박종운 (한림대학교 의과대학 흉부외과학교실) ;
  • 이재웅 (한림대학교 의과대학 흉부외과학교실) ;
  • 조태준 (한림대학교 의과대학 흉부외과학교실) ;
  • 김건일 (한림대학교 의과대학 흉부외과학교실) ;
  • 이원용 (한림대학교 의과대학 흉부외과학교실) ;
  • 홍기우 (한림대학교 의과대학 흉부외과학교실) ;
  • 엄광석 (한림대학교 의과대학 내과학교실) ;
  • 전선영 (한림대학교 의과대학 병리학교실)
  • Published : 2005.08.01
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Abstract

Combined large cell neuroendocrine carcinoma is an uncommon lung cancer that include large cell neuroendocrine carcinoma with components of adenocarcinoma, squamous cell carcinoma, giant cell carcinoma and/or spindle cell carcinoma histologically. We report a case that pathologically diagnosed as combined large cell neuroendocrine carcinoma with component of adenocarcinoma after right pneumonectomy and mediastinal lymph node dissection. A 44-year-old man with intermittent chest pain was referred to our hospital for lung mass on the right mid lung field.

혼합대세포신경내분비암종은 매우 드문 폐암으로, 조직학적으로 대세포신경내분비암종의 종양세포외에 선암종, 편평세포암종, 거대세포암종 혹은 방추상암종의 구성세포를 포함한다. 저자는 간헐적 흉부 동통을 호소하는 44세 남자환자가 우측 중폐야의폐종양으로 내원하여서 시행한 우측 폐전적 출술과 종격동 림프절 곽청술 후 병리에서 선암종의 요소를 갖는 혼합대세포신경내분비암종이 진단되어 문헌고찰과 함께 보고하는 바이이다.

Keywords

References

  1. Travis WD, Linnoila RI, Tsokos MG, et al. Neuroendocrine tumor of the lung with proposed criteria for large-cell neuroendocrine carcinoma. Am J Surg Pathol 1991;15:529-53 https://doi.org/10.1097/00000478-199106000-00003
  2. Travis WD, Rush W, Flieder DB, et al. Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid. Am J Surg Pathol 1998;22:934-944 https://doi.org/10.1097/00000478-199808000-00003
  3. Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E. Histological typing of lung and pleural tumors. In: Travis WD, Colby TC, Corrin B. Shimosato Y, Brambilla E. World Health Organization. International histological classifcation of tumours. 3rd ed. Berlin, heidelberg, New York: Springer, 1999:40-1
  4. Takei H, Asamura H, Maeshima A, et al. Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty-seven cases. J Thorac Cardiovasc Surg 2002;124: 285-92 https://doi.org/10.1067/mtc.2002.122523
  5. Doddoli C, Barlesi F, Chetaille B, et al. Large cell neuroendococrine carcinoma of the lung: An aggressive disease potentially treatable with surgery. Ann Thorac Surg 2004; 77:1168-72 https://doi.org/10.1016/j.athoracsur.2003.09.049
  6. Mazieres J, Daste G, Molinier L, et al. Large cell neuroendocrine carcinoma of the lung: pathological study and clinical outcome of 18 resected cases. Lung Cancer 2002; 37:287-91 https://doi.org/10.1016/S0169-5002(02)00099-5
  7. Zacharias J, Nicholson AG, Ladas GP, Goldstraw P. Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung: Prognosis after complete resection and systemic nodal dissection. Ann Thorac Surg 2003;75:348-52 https://doi.org/10.1016/S0003-4975(02)04118-8
  8. Kim YJ, Kim BK. Large cell neuroendocrine carcinoma of the lung. Korean J Thorac Cardiovasc Surg 2002;35:311-4
  9. Ruffini E, Rena O, Oliaro A, et al. Lung tumors with mixed histologic pattern. Clinico-pathologic characteristics and prognostic significance. Eur J Cardiothorac Surg 2002;22: 701-7 https://doi.org/10.1016/S1010-7940(02)00481-5