Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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The Role of a Second Protein (Des VIII) in Glycosylation for the Biosynthesis of Hybrid Macrolide Antibiotics in Streptomyces venezuelae

  • HONG JAY SUNG JOONG (Interdisciplinary Program of Biochemical Engineering and Biotechnology, Seoul National University) ;
  • KIM WON SEOK (Interdisciplinary Program of Biochemical Engineering and Biotechnology, Seoul National University) ;
  • LEE SANG KIL (School of Chemical and Biological Engineering, College of Engineering, Seoul National University) ;
  • KOH HWA SOO (Division of Nano Sciences and Department of Chemistry, Ewha Woman's University) ;
  • PARK HEE SUB (Division of Nano Sciences and Department of Chemistry, Ewha Woman's University) ;
  • PARK SU JIN (Division of Nano Sciences and Department of Chemistry, Ewha Woman's University) ;
  • KIM YOUN SANG (Division of Nano Sciences and Department of Chemistry, Ewha Woman's University) ;
  • YOON YEO JOON (Division of Nano Sciences and Department of Chemistry, Ewha Woman's University)
  • Published : 2005.06.01
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Abstract

The function of the desVIII gene in the pikromycin producer Streptomyces venezuelae was characterized by gene deletion and complementation analysis. In addition to the DesVII glycosyltransferase, the desVIII gene that has previously been suggested to be required for the incorporation of endogenous deoxysugar, TDP-D-desosamine, into the aglycone of pikromycin is also required for the transfer of exogenous deoxysugars, TDP-D-quinovose and TDP-D-olivose.

Keywords

References

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