Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Immunologic Alteration Demonstrated at the Economic Animal Husbandry Workers

면역독성학적 분석에 의한 축산업 종사자들의 건강 유해성 평가

  • Kim, Hyoung-Ah (The Catholic University of Korea, College of Medicine, Dept. of Preventive Medicine) ;
  • Lee, Kyung-Sook (National Institute of Rural Sciences and Technology, Rural Resources Development Institute) ;
  • Kim, Kyung-Ran (National Institute of Rural Sciences and Technology, Rural Resources Development Institute) ;
  • Kim, Kwang-Ho (Catholic University of Daegu, College of Natural Sciences, Dept. Occupational Health) ;
  • Heo, Yong (Catholic University of Daegu, College of Natural Sciences, Dept. Occupational Health)
  • 김형아 (가톨릭대학교 의과대학 예방의학교실) ;
  • 이경숙 (농업과학기술원 농촌자원개발연구소) ;
  • 김경란 (농업과학기술원 농촌자원개발연구소) ;
  • 김광호 (대구가톨릭대학교 자연대학 산업보건학과) ;
  • 허용 (대구가톨릭대학교 자연대학 산업보건학과)
  • Published : 2005.06.01
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Abstract

Economic animal husbandry workers exposed to organic dust can be suffered from immunologic disorders. Our study was to determine immunological parameters related with occurrence of respiratory allergic diseases to animal husbandry workers in Korea for the first time. Peripheral blood were obtained from twenty-five pig barn workers, forty-nine chicken farming workers and fifty-one non-agricultural control workers. Significantly upregulated plasma IgE level was observed with pig-barn workers than that of chicken farming workers or healthy community control subjects. Furthermore, level of histamine, a hallmark of allergy induction, was upregulated in the pig and chicken farming workers in comparison with that of the control subjects. Downregulation of $IFN_\gamma$ and $TNF_{\alpha}$ production from T cells was apparent in the animal husbandry workers compared with the control subjects. Meanwhile, T cells collected from the pig barn workers demonstrated significantly higher production of IL-4 and IL-10 than the other groups. There were also alterations in IgG subclass distribution. In conclusion, immunological modulation probably leading to occupational allergic diseases can be occurred in the economic animal husbandry workers and the pig barn workers could be the most risky group to the work-related allergic disease.

Keywords

References

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