Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제31권5호
  • /
  • Pages.417-421
  • /
  • 2005
  • /
  • 2234-7550(pISSN)
  • /
  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

낭종 수술 전후에 있어서 혈중 Alkaline Phosphatase의 변화에 대한 연구

CHANGES OF SERUM ALKALINE PHOSPHATASE AFTER ENUCLEATION OF CYSTS IN THE JAWS

  • 윤정주 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 이의석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 임재석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 장현석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 우현일 (고려대학교 의과대학 구강악안면외과학교실)
  • Eune, Jung-Ju (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Lee, Eui-Seok (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Rim, Jae-Suk (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Jang, Hyon-Seok (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Woo, Hyon-Il (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University)
  • 발행 : 2005.10.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study was to analyze the changes of levels of alkaline phosphatase before and after enucleation of jaw cysts combined with bone grafting, and to evaluate biochemically the effectiveness of the early detection of bone healing and infection as a prognostic marker. Eighteen patients (13 males, 5 females) with cystic lesions of the jaws were divided into two groups. The bone graft group underwent enucleation and bone graft. The control group underwent only enucleation. Both groups were measured levels of ALP before surgery, and plus-minus 4 weeks postoperatively. The more discriminating results were obtained in the bone graft group. The results were as follows : 1. Levels of ALP after enucleation of jaw cysts were decreased in all patients with and without bone graft. 2. The bone graft group showed more marked decrease in variation of levels of ALP than the control group.(p=0.008) This should be considered as a result of increased osteoblastic activity and new bone formation. 3. Such variation could be used as a prognostic marker for bone healing after cyst operation. In the cost/benefit ratio, measurement of ALP activity could be useful as a convenient procedure in routine clinical practice.

키워드

참고문헌

  1. Aubin JE, Turksen K, Heersce JMM: Osteoblastic cell Lineage In: Noda. Cellular and Molecular Biology of bone 1st ed. San Diego, CA, Academic Press. 1993:1-44
  2. Gehron Robey P, Bianco P, Termine JD: The cellular biology andmolecular biology of bone formation In: Coe FL, Flavus MJ. Disorders of Bone and Mineral Metabolism 1st ed. NY, Raven Press. 1992:241-269
  3. Doty SB: Histochemistry and enzymology of osteoclasts In: Hall BK Bone, vol.2: The osteoclast, ed. Boca Raton, CRC press. 1991:61-122
  4. Golub EE: Enzymes in mineralizing systems: state of the art. Connect Tissue Res 1996;35:183-188 https://doi.org/10.3109/03008209609029190
  5. Rodan GA, Rodan SB: Expression of the osteoblastic phenotype In: Peck WA. Bone and mineral research Annual 2, Amsterdam, Elsevier Science Publisher. 1983:244-285
  6. Einhorn TA: The cell and fracture healing. Clin Orthop 1988;355:S7-21
  7. White A, Handler P, Smith EL, Leheman IR: Principles of biochemistry 6th ed. Sydney, Mcgraw-Hill Kogakusha, 1978
  8. Gundberg CM: Biochemical markers of bone formation. Clin In Lab Med 2000;20:489-497
  9. Calvo MS, Eyre DR, Gunberg CM: Molecular basis and clinical application of biologic markers of bone turnover. Endocrine Rev 1996;17:333-368
  10. Van Hoof VO, De Broe ME: Interpretation and clinical significance of alkaline phosphatase isozyme patterns. Crit Rev Clin Lab Sci 1994;31:197-293 https://doi.org/10.3109/10408369409084677
  11. Wilkinson JH: Phosphatase Isozymes In: Isoenzymes 2nd ed. London, Chapman and Hall, 1970:239-279
  12. Bonucci BP: Endosteal surfaces in hyperparathyroidism: an enzyme cytochemical study on low-temperature-processed, glyco-methacrylate- embedded bone biopsies. Virchows Archiv Anat 1991;419:167-171 https://doi.org/10.1007/BF01626343
  13. Whyte MP: Alkaline phosphatase: physiological role explored in hypophosphatasia In: Peck WA. Bone and mineral research 6th ed. Amsterdam, Elsevier Science Publishers BV. 1989:175
  14. Ham AW, Cormack DH: Histophysiology of cartilage bone and joint. In Histology 8th ed. Philadelphia, Toronto, J.B Lippincott Co. 1979:367
  15. Robison R: The possible role of hexosphosphoric esters in ossification. Biochem J 1923;17:286 https://doi.org/10.1042/bj0170286
  16. Bhagavan NV: Biochemistry 2nd ed. Philadelphia, J.B. Lippincott. 1978:980-987
  17. Orten JM, Neuhaus OW: Biochemistry 10th ed. St Louis, Mosby. 1982:412-415
  18. Smith EL, Will RL, Lehman IR, Lefkowitz RJ, Handler P, White A: Principles of biochemistry 7th ed. Toronto, McGraw-Hill. 1983:446- 451
  19. Babicky A, Pavlik L, Kolar J, Blahos J: Effect of calcitonin on fracture healing in rats. Endocrinol Exp 1976;10:73-79
  20. Neuman WF, Distefano V, Mulryan BJ: Surface chemistry of bone, III. Observation on role of phosphatase. J Biol Chem 1951;193:227- 235
  21. Bosky AL: Current concepts of the physiology and biochemistry of calcification. Clin Orthop 1981;157:225-257
  22. Hislop WS, Finlay PM, Moos KF: A preliminary study into the uses of anorganic bone in oral and maxillofacial surgery. J Oral Maxillofac Surg 1993;31(3):149-153 https://doi.org/10.1016/0266-4356(93)90113-B
  23. Kay SA, Wisner LL, Marxer M, Lynch SE: Guided bone regeneration: Integration of a resorbable membrane and a bone graft material. Pract Periodont Aesthet Dent 1997;9:185-194
  24. Parfitt MA: The cellular basis of bone remodeling: The quantum concept reexamined in light of recent advances in the cell biology of bone. Calcif Tissue Int. 1984;36 suppl 1:s37-45 https://doi.org/10.1007/BF02406132
  25. Owen M: Lineage of osteogenic cells and their relationship to the stromal system. In: Peck WA, editor. Bone and mineral. Vol. 3. Amsterdam, Elsevier, 1985:1-25
  26. Takagi K, Urist MR: The reaction of the dura to bone morphogenetic protein (BMP) in repair of skull defects. Ann Surg 1982;196:100-109 https://doi.org/10.1097/00000658-198207000-00020
  27. Stein GS, Lian JB: Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 1993;14:424-442 https://doi.org/10.1210/edrv-14-4-424
  28. Olusola OA, Oni JP, Mahabir SJ, Gregg PJ: Serum osteocalcin and total alkaline phosphatase levels as prognostic indicators in tibial shaft fractures. Injury 1989;20:37-38 https://doi.org/10.1016/0020-1383(89)90042-9
  29. Ohishi T, takahashi M, kushida K: Changes in biochemical markers during fracture healing. Arch Orthop Trauma Surg 1988;118(3):126- 130
  30. Joerring S, Krogsgaard M, Wilbek H, Jensen LT: Collagen turnover after tibial fractures. Arch Orthop Trauma Surg 1994;113(6);334-336 https://doi.org/10.1007/BF00426183
  31. Wichmann MW, Arnoczky SP, DeMaso CM: Depressed osteoblast activity and increased osteocyte necrosis after closed bone fracture and hemorrhagic shock. J Trauma 1996;41(4):628-633 https://doi.org/10.1097/00005373-199610000-00006
  32. Moss DW, Whitby LG: A simplified heat-inactivation method for investigating alkaline phosphatase isozymes in serum. Clin Chim Acta 1975;61(1):63-71 https://doi.org/10.1016/0009-8981(75)90398-8
  33. Van Hoof VO, Lepoutre LG, Hoylaerts MF, Chevigne R, De Broe ME: Improved agarose electrophoretic method for separation alkaline phosphatase isozymes in serum. Clin Chem 1988;34(9):1857-1862
  34. Rosalki SB, Foo AY, Burlina A, Prellwitz W, Stieber P Neumeier D, et al: Multicenter evaluation of Iso-ALP test kit for measurement of bone alkaline phosphatase activity in serum and plasma. Clin Chem 1993;39(4):648-652
  35. Hill CS, Wolfert RL: The preparation of monoclonal antibodies which react preferentially with human bone alkaline phosphatase and not liver alkaline phosphatase. Clin Chim Acta 1990;186(2):315-320 https://doi.org/10.1016/0009-8981(90)90050-3
  36. Garnero P, Delmas PD: New developments in biochemical markers for osteoporosis. Calcif Tissue Int 1996:59(Suppl 1); S2-9 https://doi.org/10.1007/s002239900168
  37. Delmas PD: Biochemical markers of bone turnover for the clinical assessment of metabolic bone disease. Endocrinol Metab Clin North Am 1990;19:1-18
  38. Nyman MT, Paavolainen P, Forsius S, Lamberg-Allardt C: Clinical evaluation of fracture healing by serum osteocalcin and alkaline phosphatase. Ann Chir Gynaecol 1991;80:289-293
  39. Semb TH, Gudmundson CR, Westlin NE, Hallander LB: Alkaline phosphatase activity and isoenzymes in experimental fractures. Clin Chim Acta 1971;31(2):375-380 https://doi.org/10.1016/0009-8981(71)90406-2
  40. Reddi AH, Huggins C: Biochemical sequences in the transformation of normal fibroblasts in adolescent rats. Proc Nat Acad Sci 1972;69(6):1601-1605
  41. Hunsberger A, Jr, Ferguson LK: Variations in phosphatase and inorganic phosphorus in serum during fracture repair. Arch Surg 1932;24:1052-1060 https://doi.org/10.1001/archsurg.1932.01160180162009
  42. Semb TH, Gudmundson CR: Enzyme studies of fracture with delayed and normal union. Acta Orthop. Scand 1971;42(1):18-27
  43. Jung IH, Park SL, Chang JS: Study on the change of serum calcium, phosphorus, and alkaline phosphatase during the healing of fracture. Cent med 1975:5-29
  44. Lee HS, Lee CS, Jang JS, Lee JD, Um SM: Changes of Serum Alkaline Phosphatase and Osteocalcin during Fracture Healing. J Korean Orthop Assoc 2002;37:411-415 https://doi.org/10.4055/jkoa.2002.37.3.411
  45. Hosking DJ: Changes in serum alkaline phosphatase after femoral fractures. J Bone Joint Surg Br 1978;60(1):61-65 https://doi.org/10.2106/00004623-197860010-00008
  46. Struck H, Dabew D, Hernandez-Richter HJ, Benfer J: Klinischchemische befunde im serum bei experimenteller fraktursetzung und verschiedemer behandlung. Enzym Biol Clic 1969;10:463
  47. Alpaslan G, Alpaslan C, Bilgihan A, Yamalik K: Serum alkaline phosphatase, calcium and phosphate levels following clinical use of natural coral. Case reports. Aust Dent J 1995;40(5):327-329 https://doi.org/10.1111/j.1834-7819.1995.tb04822.x
  48. Nillson LP, Granstrom G: Changes of serum alkaline phosphatase following mandibular osteotomy in the rat. J Dent Res 1987; 66(6):1195-1198 https://doi.org/10.1177/00220345870660062001
  49. Nillson LP, Magnusson BC, Granstrom G: Enzyme histochemical analysis of tissue changes after mandibular osteotomy in an experimental systems. J anat 1985;142:117-127
  50. Granstrom G, Nilsson P, Rockert HO, Ortendal T: Studies on protracted tissue reactions and repair after circulatory and skeletal damage to the rat mandible. Int J Oral Surg 1984;13(2):151-159 https://doi.org/10.1016/S0300-9785(84)80081-2