The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Effects of Aqueous Extracts from Angelica dahurica Benth. on ${\alpha}-Melanocyte$ Stimulating Hormone-induced Melanogenesis in Bl6 Mouse Melanoma Cell

백지(白芷)의 ${\alpha}-Melanocyte$ Stimulating Hormone에 의해 유도된 Bl6 흑색종 세포의 멜라닌 형성에 미치는 영향

  • 홍의석 (동의대학교 한의과대학 안이비인후피부과교실) ;
  • 이준혁 (동의대학교 한의과대학 해부학교실) ;
  • 최병태 (동의대학교 한의과대학 해부학교실) ;
  • 윤화정 (동의대학교 한의과대학 안이비인후피부과교실) ;
  • 고우신 (동의대학교 한의학임상연구센터)
  • Published : 2005.04.25
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Abstract

Melanin determines phenotypic appearance and its election-opaque property protects cells from physical, including ultraviolet (UV) radiation, and chemical stimuli such as free radicals. However hyper-pigmentation is associated with various skin diseases such as keloid scar. The aim of present study was to investigate the effects of aqueous extracts from Angelica dahurica Benth. (AEAD) on ${\alpha}-Melanocyte$ stimulating hormone $({\alpha}-MSH)-induced$ melanogenesis in B16 mouse melanoma cell. Relative high doses ($5\;mg/m{\ell}$) of AEAD could inhibit melanin formation without apoptotic death in cells treated with ${\alpha}-MSH$. And also, ${\alpha}-MSH-induced$ activation of tyrosinase was inhibited in cells treated with AEAD. These results suggest that AEAD inhibit melanogenesis through inhibiting tyrosinase activity, and also, AEAD may apply to develop whitening drugs and cosmetics.

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