Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Neuropharmacological screening of the methanolic extract of Hibiscus vitifolius flowers

  • Seethalakshmi, S (Department of Pharmacology, Sri Ramachandra Medical College and Research Institute (Deemed University)) ;
  • Chamundeeswari, D (Sri Ramachandra College of Pharmacy, Sri Ramachandra Medical College and Research Institute (Deemed University)) ;
  • Rani, S Jamuna (Department of Pharmacology, Sri Ramachandra Medical College and Research Institute (Deemed University)) ;
  • Parvathavardhini, S (Department of Pharmacology, Sri Ramachandra Medical College and Research Institute (Deemed University)) ;
  • Vasantha, J (Sri Ramachandra College of Pharmacy, Sri Ramachandra Medical College and Research Institute (Deemed University))
  • Published : 2005.12.30
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Abstract

The methanolic extract of Hibiscus vitifolius flowers (HVE), was evaluated for neurophamacological activities by carrying out rota rod, locomotor activity and traction performance in mice and swim endurance activity in rats in different dosages (10, 30 and 100mg/kg body weight). HVE showed a significant effect on central nervous system by increasing the time taken for rota rod, traction performance and locomotor activity while swimming time was found to be decreased when compared to normal control animals. These results suggest that HVE possess significant anxiolytic and anti depressant activity which may be attributed to the presence of flavonoid in HVE.

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References

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