Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Effects of QZ-16 on blood glucose and lipids in Streptozotocin induced diabetic rats

  • Najmi, Abul K. (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University)) ;
  • Pillai, K.K. (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University)) ;
  • Ahmad, Aftab (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University)) ;
  • Aqil, M. (Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University))
  • Published : 2005.06.30
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Abstract

The present study was designed to investigate the hypoglycaemic and hypolipidaemic activities of Qurs-e-Ziabetus 16 (QZ-16) in Streptozotocin (STZ) induced diabetic rats. QZ-16, a polypharmaceutical herbomineral formulation developed on the principles of Unani medicine is used for non-insulin dependent diabetes mellitus (NIDDM). The elevated levels of fasting blood glucose, serum levels of cholesterol, triglycerides and urea observed in rats treated with STZ (55 mg/kg body wt.) were significantly reduced by the treatment of QZ-16 (240 mg/kg, p.o.) and gliclazide (30 mg/kg, p.o.). The reduced HDL cholesterol levels were also increased by the QZ-16 and gliclazide treatments in the STZ induced diabetic rats. These data show that QZ-16 has hypoglycaemic, hypolipidaemic properties in STZ induced diabetic rats.

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References

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