Journal of Pharmaceutical Investigation

  • 제35권1호
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  • Pages.1-5
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  • 2005
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  • 2093-5552(pISSN)
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  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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The Effect of Solvents on Sold Dispersion of Ipriflavone with Polyvinylpyrrolidone In Vivo

  • Jeong, Je-Kyo (Research Center, Samchundang Pharm. Co. Ltd.) ;
  • Ahn, Yong-San (Department of Polymer. Nano Science and Technology, Chonbuk National University) ;
  • Moon, Byung-Kwan (Department of Advanced Organic Materials Engineering, Chonbuk National University) ;
  • Choi, Myung-Kyu (Department of Polymer. Nano Science and Technology, Chonbuk National University) ;
  • Khang, Gil-Son (Department of Polymer. Nano Science and Technology, Chonbuk National University, Department of Advanced Organic Materials Enginnering, Chonbuk National University, Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Rhee, John-M. (Department of Polymer. Nano Science and Technology, Chonbuk National University, Department of Advanced Organic Materials Enginnering, Chonbuk National University) ;
  • Lee, Hai-Bang (Department of Polymer. Nano Science and Technology, Chonbuk National University, Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
  • 발행 : 2005.02.20
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초록

ABSTRACT -Ipriflavone is a synthetic flavonoid derivate that improves osteoblast cell activity inhibiting bone resorption. In order to improve the bioavailability, solid dispersions of ipriflavone with PVP (poly-N-vinylpyrrolidone, MW=40,000 g/mole) were prepared by a spray-drying method. During the manufacturing of solid dispersion, various solvents [ethanol (EtOH), acetonitrile, methylene chloride and cosolvent-EtOH:acetone=1:1] were used to dissolve the ipriflavone and PVP. Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) were used to evaluate the physicochemical interaction between ipriflavone and PVP. Particle size, crystallinity and the area of the endotherm $({\Delta}H)$ of solid dispersed ipriflavone using the acetonitrile as solvent were much smaller than those of the other preparation types. Bioavailability of ipriflavone in vivo was changed by solvents. When considering the result of in vivo test, solid dispersion of ipriflavone using the acetonitrile as solvent showed the best choice.

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