Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
권호 표지

Inhibitory Effects of Chinese Medicinal Plants on the Platelet-Activating Factor (PAF) Receptor Binding

중국 약용식물의 혈소판 활성화인자 수용체 결합 억제활성

  • Kang, Young-Hwa (Division of Applied Life Science, College of Agricultural and Life Science, Kyungpook National University)
  • 강영화 (경북대학교 농업생명과학대학 응용생명과학부)
  • Published : 2005.08.30
Download PDF
⟨ Previous Next ⟩

Abstract

Methanolic extracts of fifteen Chinese medicinal plants were screened for platelet-activating factor (PAF) receptor binding inhibitory activity using rabbit platelet. Campsis grandiflora, Dalbergia odorifera, Vaccaria segetalis and Zanthoxylum nitidum showed significant inhibitory effects on the platelet-activating factor (PAF) receptor binding. Campsis grandiflora, Dalbergia odorifera, Vaccaria segetalis and Zanthoxylum nitidum inhibited 52%, 56%, 70%, and 66% respectively at the concentration of 0.2 mg/ml.

15종의 항어혈성 중국 약용식물의 추출물에 대하여 PAF 수용체 결합 억제활성을 검색한 결과 4종의 약용식물, Campsis grandiflora, Dalbergia odorifera, Zanthoxylum nitidum, Vaccaria segetalis에서 50% 이상의 강한 PAF 결합 저해 활성이 나타났다.

Keywords

References

  1. Blood Vessel. v.70 BN 52021 and related compounds ; a new series of highly specific PAF-acether receptor antagonists isolated from Ginkgo biloba Braquet, P.;Spinnewyn, B.;Braquet, M.;Bourgain, R.H.;Taylor, J.E.;Etienne, A.;Drieu, K.
  2. Pharmacol. Rev. v.39 Perspectives in Platelet-activating Factor Research Braquet, P.;Tougui, L.;Shen, T.Y.;Vargaftig, B.B.
  3. Adv Exp Med BioI. v.416 Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis Curtis, L.M.
  4. Nat. Prod. Sci. v.7 Evaluation of inhibitory potentials of Chinese medicinal plants on platelet-activating factor (PAP) receptor binding Fan, G.J.;Han, B.H.;Kang, Y.H.;Park, M.K.
  5. Kor. J. Pharmacogn v.39 Screening of the inhibitory effect of herbal medicines on the platelet activating factor (PAF) binding: 35 selected herbal medicines based on folk medicinal informations Han, B.H.;Yang, H.O.;Kang, Y.H.;Han, Y.N. https://doi.org/10.1111/j.1440-1673.1995.tb00223.x
  6. Annu. Rev. Biochem. v.55 Platelet activating factor : A biologically active phosphoglyceride Hanahan, D.J. https://doi.org/10.1146/annurev.bi.55.070186.002411
  7. Kor. J. Pharmacogn v.33 Quantitative Analysis of 20-Hydroxyecdysonein Melandrii Herba Kim, H.K.;Lee, H.W.;Hwang, S.W.;Ko, B.S.
  8. Am. J. Pathol. v.122 Platelet activating factor-induced ischemic bowel necrosis Hsueh, W.;Gonzalez, C.F.;Arrovave, J.L.
  9. Lab. Invest. v.51 Hyperacute renalallograft rejection in the rabbit : the role of platelet-activating factor and of cationic proteins derived from polymorphonuclear leucocytes and from platelets Ito, O.;Camussi, G.;Tetta, C.;Milgrom, F.;Andres, G.
  10. Nat. Prod. Sci. v.2 Inhibitory effect of Malaysian medicinal plants on the platelet activating factor (PAF) binding Jantan, I.B.;Kang, Y.H.;Suh, D.Y.;Han, B.H.
  11. Drugs v.42 Platelet activating factor (PAP). A review of its effects, antagonists, and possible future clinical implications (Part I) Koltai, M.;Hosford, D.;Guinot, P.;Esanu, A.;Braquet, P. https://doi.org/10.2165/00003495-199142010-00002
  12. YAKHAK HOEJI v.37 Isolation and Biological Activity of Verbascoside, A Potent Inhibitor of Protein Kinase C from the Calyx of Campsis grandiflora Lee, H.S.;Park, M.S.;Oh, W.K.;Ahn, S.C.;Kim, B.Y.;Kim, H.M.;Oh, G.T.;Mheen, T.I.
  13. Rapid Commun Mass Spectrum v.19 Liquid chromatography/electrospray ionization mass spectrometry for the characterization of twenty-three flavonoids in the extract of Dalbergia odorifera Liu, R.;Ye, M.;Guo, H.;Bi, K.;Guo, A. https://doi.org/10.1002/rcm.1936
  14. Asian Nat Prod Res v.1 Triterpenoid saponins from Vaccaria segetalis Sang, S.;Lao, A.;Wang, H.;Chen, Z.;Uzawa, J.;Fujimoto, Y. https://doi.org/10.1080/10286029908039865
  15. Med. Res. Rev. v.5 Chemical and biochemical aspects of platelet activating factor : a novel class of acetylated ether-linked choline phospholipids Snyder, F. https://doi.org/10.1002/med.2610050105
  16. Korean J. Food Sci. Technol. v.34 Identification of Antioxidative Components from Ethanol Extracts of Dalbergia odorifera T, CHEN Choi, U.;Kim, I.W.;Baek, N.I.;Shin, D.H.
  17. Food Sci. Biotechnol. v.12 Antioxidative and Synergistic Effect of Ethanol Extracts from Dalbergia odorifera T. CHEN Choi, U.;Kim, I.W.;Shin, D.H.
  18. J. Immunol. v.129 Specific binding ofphospholipid platelet-activating factor by human platelets Valone, F.H.;Coles, E.;Reinhold, V.R.;Goetzl, E.J.
  19. Br. Med. Bull. v.43 PAF-acether today : relevance for acute experimental anaphylaxis Vargaftig, B.B.;Braquet, P. https://doi.org/10.1093/oxfordjournals.bmb.a072185
  20. Life Sci. v.74 Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts Wang, S.;Zheng, Z.;Weng, Y.;Yu, Y.;Zhang, D.;Fan, W.;Dai, R.;Hu, Z. https://doi.org/10.1016/j.lfs.2003.03.005
  21. Arch Pharm Res. v.27 no.4 Anti-platelet pentacyclic triterpenoids from leaves of Campsis grandiflora Jin, J.L.;Lee, Y.Y.;Heo, J.E.;Lee, S.;Kim, J.M.;Yun-Choi, H.S. https://doi.org/10.1007/BF02980076