Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Quantitative Analysis of Anthraquinone and Stilbene Derivatives in Various Rhubarbs

대황류 생약의 인트라퀴논 및 스틸벤 유도체 함량분석

  • Published : 2005.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study was carried out to obtain the basic information that can be used to index rhubarbs in six regions of China and Korea. The anthraquinone and stilbene contest in various rhubarb produced in th different area were quantitatively analysed by HPLC. The average of sennoside A content of the Chinghai rhubarb was higher than that of the other palmata rhubarbs(high-quality rhubarbs) produced in China. As a result, the order of the sennoside A content was 1) Chinghai rhubarb, 2) Tsuchan rhubarb, 3)Kansu rhubarb 4) Neimenggu rhubarb. On the other hand, the total stilbenes content of each of the cultivated Korean rhubarb(Rheum undulatum) were higher than that of the Chinese rhapontica rhubarb(low-quality rhubarbs).

Keywords

References

  1. 高木敬玖次郞 等(1985) 和漢藥物學, 229-235. 南山堂, 東京
  2. 難波恒雄 (1993) 和漢藥百科圖鑑(1), 16-20. 保育祉, 大阪
  3. Uuchibayshi, M. and Matsuoka, T. (1961) Aloe-emodin( Notes). Chem. Pharm. Bull. 9: 234-236 https://doi.org/10.1248/cpb.9.234
  4. Okabe, H., Matsuo, K. and Noshioka, I. (1973) Studies on rhubarb (Rhei Rhizoma) II, anthraquinone glycosides. Chem.Pharm. Bull. 21: 1254-1260 https://doi.org/10.1248/cpb.21.1254
  5. Oshio, H. (1978) Investigation of Rhubarbs (IV). Isolation of sennoside D, citreorosein and laccaic acid. Shoyakugaku zasshi 32: 19-23
  6. Holzschuh, L., Kopp, B. and Kubelka, W. (1982) Physcion-8-O-$\beta$-D-gentiobioside, a new anthraquinone glycoside from rhubarb roots. Planta med. 46: 159-161 https://doi.org/10.1055/s-2007-970042
  7. Khetwal, K. S. and Pathak, R. P. (1988) Active anthraquinoids from Rheum webbianum. J Indian Chem. Soc. 65: 227-227
  8. Rawat, M. (1989) Anthraquinone glycosides from Reum moorcofitianum. Phamazia. 44: 509-510
  9. Tsukida, K. and Yoneshige, M. (1954) Studies on the constituents of Polygonaceous plants. IV. Constituents of Japanese rhubarb (Rheum palmatum). Yakugaku zassi 74: 382-383 https://doi.org/10.1248/yakushi1947.74.4_382
  10. Ko, S. K., Whang, W. K. and Kim, I. H. (1995) Anthraquinone and stilbene derivatives from cultivated Korean rhubarb rhizomes. Arch. Pharm. Res. 18: 282-288 https://doi.org/10.1007/BF02976414
  11. Ko, S. K. (2000) A new stilbene diglycoside trom Rheum undulatum. Arch. Pharm. Res. 23: 159-162 https://doi.org/10.1007/BF02975506
  12. Miyamoto, M., Imai, S., Shinohara, M. and Fusioka, S. (1967) Studies on the purgative substance I, Isolation of sennoside A, one of the most active priciples from rhubarbs. Yalatgalat Zasshi 87: 1040-1043
  13. Miyamoto, M., Imai, S., Shinohara, M. and Fusioka, S. (1972) Investigation of rhubarb II, Isolation of sennoside E. a new purgative compound. Chem. Pharm. Bull. 20: 621-624 https://doi.org/10.1248/cpb.20.621
  14. Oshio, H., Imai, S., Fujioka, S., Sugawara, T. and Miyamoto, M. (1974) Investigation of rhubarb III, New purgative constituents, sennoside E and F. Chem. Pharm. Bull. 22: 823-83l https://doi.org/10.1248/cpb.22.823
  15. Yamagishi, T., Nishizawa, M., lkura, M., Hikichi, K., Nonaka, G and Nishioka, I. (1987) New laxative constituents of rhubarb, Isolation and chracterization of rheinosides A,B,C and D. Chem. Pharm. Bull. 35: 3132-3138 https://doi.org/10.1248/cpb.35.3132
  16. Yaki, A., Koizumi, Y and Nishioka, I. (1971) Studies onrhubarb( Rhei Rhizoma) I, stilbene derivatives from 'dodaioo' (Chinese inferior rhubarb). Shoyalatgalat Zasshi 25: 52-54
  17. Kashiwada, Y, Nonaka, G and Nishioka, I. (1984) Tannins and related compound XXIII, rhubarb(4), isolation and structure of new classes of gallotannin. Chem. Pharm. Bull. 32: 3461-3470 https://doi.org/10.1248/cpb.32.3461
  18. Kashiwada, Y, Nonaka, G and Nishioka, I. (1984) Studies on rhubarb(Rhei Rizoma) VI, isolation and characterization of stilbene. Chem. Pharm. Bull. 32: 3501-3517 https://doi.org/10.1248/cpb.32.3501
  19. Kashiwada, Y, Nonaka, G, Nishioka, I., Nishizawa, M. and Yamagishi, T. (1988) Studies on rhubarb (Rhei Rhizoma) XIV, isolation and characterization of stilbene glycosides from Chinese rhubarb. Chem. Pharm. Bull. 36: 1545-1549 https://doi.org/10.1248/cpb.36.1545
  20. Ko, S. K. Whang, W. K. and Kim, I. H. (1998) Stilbene compounds from cultivated Korean rhubarb rhizomes. YakhakHoeji. 42: 1-4
  21. Kashiwada, Y., Nonaka, G and Nishioka, I. (1989) Studies on rhubarb (Rhei Rhizoma). XV. Simultaneous determination of phenolic constituents by high-rformance liquid chromatography. Chem. Pharm. Bull. 37: 999-1004 https://doi.org/10.1248/cpb.37.999
  22. Matsuoka, T. (1961) Pharmacognostic studies on rhubarb. Shoyalatgalat Zasshi 15: 113-148
  23. Kobashi, K., Nishimura, T., Kusaka, M., Hattori, M. and Namba, T. (1980) Metabolism ofsennosides by human intestinal bacteria. Planta Med. 40: 225-236 https://doi.org/10.1055/s-2008-1074963
  24. Hattori, M. (1982) Mechanism of sennosides by intestinal flora. Chem. Pharm. Bull. 30: 1338-1346 https://doi.org/10.1248/cpb.30.1338
  25. Ko, S. K, Shin, C. G, Lee, H. S., Han, S. T., Yang, B. W., Im, B. O. and Chung, S. H. (2004) Effect of stilbene derivatives from Rheum undulatum on carrageenin-induced acute edema in rats. Kor. J. Pharmacogn. 35: 171-174
  26. Ko, S. K., Lee, C. R., Lee, H. S., Kim, H., Baek, K. H., Tokuoka, K and Chung, S. H. (2003) Inhibitory effects of stilbene derivatives from Rheum undulatum on cyclooxygenase activity. Kor. J. Pharmacogn. 34: 25-27
  27. Matsuda, H., Tomohiro, N., Hiraba, K, Harima, S., Ko, S. K., Matsuo, K., Yoshikawa, M. and Kubo, M. (2001) Study on anti-oketsu activity of rhubarb II. Anti-allergic effects of stilbene components from Rhei undulati Rhizoma(dried rhizome of Rheum undulatum cultivated in Korea). BioI. Pharm. Bull. 24: 264-267 https://doi.org/10.1248/bpb.24.264
  28. Ko, S. K., Lee, S. M. and Whang, W. K. (1999) Anti-platelet aggregation activity of stilbene derivatives from Rheum undulatum. Arch. Pharm. Res. 22: 401-403 https://doi.org/10.1007/BF02979065
  29. Ko, S. K., Lee, S. M. and Whang, W. K. (1999) Effects of Rheum plants on blood platelet aggregation. Yakhak Hoeji 43: 233-236
  30. Kubo, M., Ko, S. K., Harifua, S., Matsuda, H. and Kim, I. H. (1998) Study on anti-oketsu activity of rhubarb I. Pharmacological efficacy of rhubarb (Rheum undulatum 1.) cultivated in Korea. J. Traditional Med. 14: 237-244