Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Effect of Kikkanol F Monoacetate and 5-Hydroxy-6,7,3',4'-tetramethoxyflavone Isolated from Chrysanthemum indicum L. on IL-6 Production

감국에서 분리한 Kikkanol F Monoacetate와 5-Hydroxy-6,7,3',4'-tetramethoxyflavone의 IL-6 생성억제활성

  • Nam, Jung-Yeon (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyun-Sun (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Seung-Woong (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Chung, Mi-Yeon (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Choe, Jeong-Ho (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Yoo, Eun-Sook (Department of Pharmacology, College of Medicine, Cheju National University) ;
  • Kim, Young-Kook (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Rho, Mun-Chual (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
  • 남정연 (한국생명공학연구원 지질대사연구실) ;
  • 이현선 (한국생명공학연구원 지질대사연구실) ;
  • 이승웅 (한국생명공학연구원 지질대사연구실) ;
  • 정미연 (한국생명공학연구원 지질대사연구실) ;
  • 최정호 (한국생명공학연구원 지질대사연구실) ;
  • 유은숙 (제주대학교 의과대학) ;
  • 김영국 (한국생명공학연구원 지질대사연구실) ;
  • 노문철 (한국생명공학연구원 지질대사연구실)
  • Published : 2005.09.30
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Abstract

Searching for inhibitors of lipopolysaccharide (LPS)-induced IL-6 (Interleukin-6) production from medicinal herbs, we isolated two active compounds though bioactivity-guided fractionation from the methanol extract of Chrysanthemum indicum L.. They were determined as kikkanol F monoacetate (1) and 5-hydroxy-6,7,3',4'-tetramethoxyflavone (2) by means of spectroscopy techniques such as NMR and MS. The compound 1 and 2 inhibited LPS-induced IL-6 production in the PAW264.7 cells with $IC_{50}$ value of $47\;{\mu}g/ml$ and $27\;{\mu}g/ml$, respectively.

Keywords

References

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