Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Nelumbo nucifera Leaves on Hyperlipidemic and Atherosclerotic Bio F1B Hamster

고지혈증 및 동맥경화 감응 Bio F1B 햄스터에서 연잎(Nelumbo nucifera)의 지질저하 효과

  • Kim, Sung-Bin (Division of Applied Bioscience, Mokpo National University) ;
  • Rho, Sung-Bae (Dept. of Food Processing & Baking, Yangsan College) ;
  • Rhyu, Dong-Young (Division of Applied Bioscience, Mokpo National University) ;
  • Kim, Dong-Wook (Division of Applied Bioscience, Mokpo National University)
  • 김성빈 (목포대학교 응용생명과학부 생약자원) ;
  • 노승배 (양산대학 식품가공제과제빵학과) ;
  • 류동영 (목포대학교 응용생명과학부 생약자원) ;
  • 김동욱 (목포대학교 응용생명과학부 생약자원)
  • Published : 2005.09.30
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Abstract

Nelumbo nucifera Gaertner leaf (NNL) has been known that is effective to lowering blood pressure and hyperlipidemic levels. But, its pharmacological actions have not been demonstrated. Therefore, the present research was performed to find the effect of NNL on hyperlipidemic actions in Bio F1B hamster as a model for hyperlipidemia and atherosclerosis. The hyperlipidemic hamster were induced by basal diet containing 10% coconut oil and 0.05% cholesterol with high fat atherogenic diet(HFAD). A control group and treated groups NNL100, 200, 400 mg/kg/day were fed a HFAD, but a normal group was fed a basal diet only. In conclusion, the serum total cholesterol levels were significantly declined on day 40 in F1B hamster given the NNL extracts (200, 400 mh/kg/day) with p<0.05, when compared with a control value of HFAD fed hamsters. The hepatic TC level was significantly lower in NNL 200 and 400 mg/kg/day group than of control hamster on day 40. But, the HDL levels were not changed between control and treated NNL groups. The TG levels of NNL treated groups showed a decrease tendency compare to the control value. In addition, accumulation of fatty level showed a slight decline to NNL treated groups in aortic arch.

Keywords

References

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