Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Honokiol : A Noncompetitive Tyrosinase Inhibitor from Magnoliae Cortex

  • Tian, Yu-Hua (Phytofermentation Research Center and College of Pharmacy, Wonkwang University) ;
  • Kang, Tai-Hyun (Phytofermentation Research Center and College of Pharmacy, Wonkwang University) ;
  • Kim, Hyun-Chul (Phytofermentation Research Center and College of Pharmacy, Wonkwang University) ;
  • Kim, Youn-Chul (Phytofermentation Research Center and College of Pharmacy, Wonkwang University)
  • Published : 2005.06.01
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Abstract

Effect of the neolignans, honokiol (1) and magnolol (2), isolated from Magnoliae Cortex on mushroom tyrosinase activity was investigated in vitro using L-tyrosine as a substrate. Honokiol (1) inhibited tyrosinase activity significantly in a concentration-dependent manner, on the other hand, magnolol (2) did not show tyrosinase inhibitory effect. Honokiol exhibited tyrosinase inhibitory effect with $IC_{50}$ value of $67.9\;{\mu}M$, and proved to act as a non-competitive inhibitor by the analysis of Lineweaver-Burk plot.

Keywords

References

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