Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Coumarins and Chromones from Angelica genuflexa

  • An, Ren-Bo (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology,College of Pharmacy, Yanbian, University) ;
  • Park, Bo-Young (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Jung-Hee (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kwon, Ok-Kyoung (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Joong-Ku (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology) ;
  • Min, Byung-Sun (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology) ;
  • Ahn, Kyung-Seop (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology) ;
  • Oh, Sei-Ryang (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyeong-Kyu (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2005.06.01
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Abstract

Thirteen compounds were isolated from the roots of Angelica genuflexa through repeated silica gel column chromatography. Nine coumarins, isoimperatorin (1), osthol (2), demethylsuberosin (3), oxypeucedanin (4), heraclenin (5), pabulenol (7), umbelliferone (8), oxypeucedanin hydrate (9) and marmesinin (11), and four chromones, hamaudol (6), cimifugin (10), sec-O-glucosylhamaudol (12) and prim-O-glucosylcimifugin (13), were identified by physicochemical and spectroscopic analysis. Among these, compounds 3, 5, 6, 8, 12, and 13 were isolated for the first time from the roots of Angelica genuflexa. These coumarins and chromones were examined for their anticomplement activity. Demethylsuberosin (3) showed a weak anticomplement activity with an $IC_{50}$ value of $390\;{\mu}M$.

Keywords

References

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