Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anti-inflammatory Activity of a Flavonol Glycoside from Tephrosia Spinosa

  • Published : 2005.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

A rare flavonol glycoside identified as $eupalitin-3-O-{\beta}-D-glucoside$ (I) was isolated from Tephrosia spinosa (Leguminosae) and its anti-inflammatory activity was evaluated against carrageenin induced paw edema. The compound exhibited significant activity when compared to the standard drug indomethacin.

Keywords

References

  1. Agarwal, R.B. and Rangari, V.D., Anti-inflammatory and Antiarthritic activities of Lupeol and 19a-H Lupeol isolated from Strobilanthus callosus and Strobilanthus ixiocephala roots. Ind. J. Pharmacol. 35, 384-387 (2003)
  2. Al-Haboubi, H.A. and Zeitlin, I.J., Re-appraisal of the role of histamine. in carrageenan-induced paw oedema. Eur. J. Pharmacol. 88, 169-176 (1983) https://doi.org/10.1016/0014-2999(83)90003-1
  3. Jang, D.S., Park, E.J., Kang, Y.H., Hawthrone, M.E., Vigo, J.S., Graham, J.G., Cabieses, F., Fong, H.H.S., Mehta,R., John M. Pezzuto, J.M., and Kinghorn, D.A., Potential cancer chemopreventive flavonoids from the stems of Tephrosia toxicaria, J. Nat. Prod. 66, 1166-1170 (2003) https://doi.org/10.1021/np0302100
  4. Deshpande, S.S., Shah, G.B., and Parmar, N.S., Antiulcer activity of Tephrosia purpurea in rats. Indian J. Pharmacol 35, 168-172 (2003)
  5. Duwiejua, M., Zeitlin, I.A., Waterman, P.G., and Gray A.I., Anti-Inflammatory activity of Polygonum bistorta, Guaiacum officinale and Hamamelis virginiana in rats. J. Pharm. Pharmacol. 46, 286-290 (1994) https://doi.org/10.1111/j.2042-7158.1994.tb03795.x
  6. Gokhale, A.B. and Saraf, M.N., Influence of Ethanolic extract of Tephrosia purpurea Linn. on the late-phase of allergic reaction. Indian J. Pharm. Sci., Sep-Oct, 356-359 (2000)
  7. Gokhale, A.B. and Saraf, M.N., Studies on antiallergic activity of ethanolic extract of Tephrosia purpurea Linn. Indian Drugs 37, 228-232 (2000)
  8. Jagat, P.S. Sarin, Satyawan Singh, Garg, H.S., Khanna, N.H., and Dhar, M.M., A Flavonol glycoside with Anticancer activity from Tephrosia candida. Phytochem. 15, 232-234 (1976) https://doi.org/10.1016/S0031-9422(00)89101-3
  9. Kapil, A., and Sharma S., Effect of oleanolic acid on complement in adjuvant and carrageenan-induced inflammation in rats. J. Pharm. Pharmacol. 47, 585-587 (1995) https://doi.org/10.1111/j.2042-7158.1995.tb06719.x
  10. Chang, L.C., Gerhauser, C., Song, K., Fransworth, N.R., Pezzuto, J.M., and Kinghorn, D.A., Activity guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase-Il Enzyme, Quinone Reductase. J. Nat. Prod. 60, 869-873 (1997a) https://doi.org/10.1021/np970236p
  11. Cheng, L.C., Chavez, D.L., Song, L.L., Fransworth, N.R., Pezzuto, J.M., and Kinghorn, D.A., Absolute configuration of Novel bioactive flavonoids from Tephrosia purpurea. Org. Lett. 2, 515-518 (2000b) https://doi.org/10.1021/ol990407c
  12. Rongzhi, L., Nianbai, F., and Mabry, T.J., Flavonoids from Brickellia scoparia. J. Nat. Prod. 19, 732-733 (1986)
  13. Pirrung, M.C. and Lee, Y.R., Total Synthesis and absolute configuration of Pseudosemiglabrin, a Platelet aggregation antagonist and its Diastereomer Semiglabrin. J. Chem. Soc. 117, 4814-4821 (1995) https://doi.org/10.1021/ja00122a011
  14. Mitra, S.K., Venkataranganna, M.V., Sundaram, R., and Gopumad-havan, S., Protective Effect of HD-03, A herbal formulation against various hepatotoxic agents in rats. J. Ethanopharmacol. 63, 181-186 (1998) https://doi.org/10.1016/S0378-8741(98)00088-9
  15. Saleem, M., Ahmed, S.U., Alam, A., and Sultana, S., Tephrosia purpurea alleviates Phorbol Ester induced Tumor promotion response in murine skin. Pharmacol. Res. 43, 135-144 (2001) https://doi.org/10.1006/phrs.2000.0711
  16. Ravi, K.K., Krishan, A.S., Suri, O.P., and Chand K.A, 3,5,4'-trihydroxy-6,7-dimethoxyflavone 3-glucoside from Sesuvium portulacastrum. Phytochem. 21, 1179-1180 (1982) https://doi.org/10.1016/S0031-9422(00)82450-4
  17. Sanchez, I., Gomez-Garibay, Taboada, J., and Ruiz, B.H., Antiviral effects of flavonoids on the Dengue virus. Phytother. Res. 14, 89-92 (2000) https://doi.org/10.1002/(SICI)1099-1573(200003)14:2<89::AID-PTR569>3.0.CO;2-C
  18. Murthy, M.S.R., Rao, E.V., Dhawan, B.N., and Panaik, G.K., Antispasmodic activity of certain Maxima isoflavones. Indian J. Pharm. Sci., Sep-Oct. 140-141 (1986)
  19. Thangam, C. and Dhananjayan, R., Anti-inflammatory potential of the seeds of Carum copticum Linn., Ind. J. Pharmacol. 35, 388-391 (2003)
  20. Rao, E.V. and Prasad, Y.R., Two chalcones from Tephrosia spinosa. Phytochem. 31, 2121-2122 (1992a) https://doi.org/10.1016/0031-9422(92)80376-P
  21. Rao, E.V. and Prasad, Y.R., Prenylated Flavonoids from Tephrosia spinosa. Phytochem. 32, 183-185 (1993b) https://doi.org/10.1016/0031-9422(92)80129-3
  22. Vinegar, R., Schreiber, W., and Hugs, R., Biphasic development of carrageenan oedema in rats. J. Pharmac. Exp. Ter. 166, 9598 (1969)
  23. Winter, C.A., Risley, E.A, and Nuss, G. W., Carrageenan induced oedema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 111, 544-547 (1962)