대한한의학방제학회지 (Herbal Formula Science)

  • 제13권1호
  • /
  • Pages.35-48
  • /
  • 2005
  • /
  • 1229-1218(pISSN)
  • /
  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지

CT99 발현 PC12 세포주에서 가감고본환의 신경보호 및 항치매 효과

Effect of the neuroprotetion and anti-Alzheimer's disease in CT99-induced PC12 cells by Gakamgobonhwan water extract

  • 안대광 (대구한의대학교 한의학과 내과학) ;
  • 이소연 (대구한의대학교 한의학과 내과학) ;
  • 윤현덕 (대구한의대학교 한의학과 내과학) ;
  • 신오철 (대구한의대학교 한의학과 내과학) ;
  • 박창국 (대구한의대학교 한의학과 내과학) ;
  • 박치상 (대구한의대학교 한의학과 내과학)
  • Ahn, Dae-Gwang (Department of Oriental Medicine Graduate school of Daegu Haany University) ;
  • Lee, So-Yeon (Department of Oriental Medicine Graduate school of Daegu Haany University) ;
  • Yoon, Hyeon-Deok (Department of Oriental Medicine Graduate school of Daegu Haany University) ;
  • Shin, Wo-Cheol (Department of Oriental Medicine Graduate school of Daegu Haany University) ;
  • Park, Chang-Gook (Department of Oriental Medicine Graduate school of Daegu Haany University) ;
  • Park, Chi-Sang (Department of Oriental Medicine Graduate school of Daegu Haany University)
  • 발행 : 2005.06.30
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초록

Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the biggest problem in public health service. It has been widely believed that $A{\beta}$ peptide devided from APP causes apoptotic neurotoxicity in brain. However, recent evidence suggests that n99 may be an important factor causing neurotoxicity in AD. Mouse PC12 cells expressed with n99 exhibited remarkable apoptotic cell damage. We invesgated the protective effects of Gagamgobonhwan water extract(GKG). Findings from our experiments have shown that GKG inhibits the activities of CT99, which has neurotoxicities and apoptotic activities in cell line. In addition, treatment of GKG($75{\mu}g/ml$ 24 hours) partially prevented CT99-induced cytotoxicity in PC12 cells. As the result of this study, in GKG group the apoptosis in the nervous system was inhibited, the repair against the degerneration of PC12 cells by CT99 expression is promoted. Taken together, GKG exhibited inhibition of CT99-induced apoptotic cell death. GKG may be beneficial for the treatment of AD.

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