Herbal Formula Science (대한한의학방제학회지)
- Volume 13 Issue 1
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- Pages.71-83
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- 2005
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- 1229-1218(pISSN)
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- 2288-5641(eISSN)
The Effects of Chelidonii Herba Extract on Apoptosis in Human Stomach Adenocarcinoma Cell Line
백굴채(白屈菜)가 Stomach Adenocarcinoma Cell Line의 Apoptosis에 미치는 영향
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Kim, Sang-Chan
(Dept of Formulae Pharmacology, College of Oriental Medicine, Daegu Haany University) ;
- Lee, Sang-Tae (Dept of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
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Kim, Dae-Jun
(Dept of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
- Byun, Joon-Seok (Dept of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
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김상찬
(대구한의대학교 한의과대학 방제학교실) ;
- 이상태 (대구한의대학교 한의과대학 내과학교실) ;
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김대준
(대구한의대학교 한의과대학 내과학교실) ;
- 변준석 (대구한의대학교 한의과대학 내과학교실)
- Published : 2005.06.30
Abstract
Chelidonii Herba (Baekgulchae in Korean: CHE), a commonly used herb in Korea, Japan and China, is widely used in the treatment of stomach cancer, jaundice, gastric ulcer, edema and pain of stomach. In the present study, we demonstrated that CHE induces apoptosis in AGS cells, human stomach adenocarcinoma cell line. One of the most important recent advances in cancer research is the recognition that apoptosis plays a major role in both tumor formation and treatment response, In this study, CHE caused a decrease of viability in AGC cells. When AGS cells were treated with CHE, cells showed dose-dependent manner apoptotic cell death. Increased apoptotic cell death, exposured to CHE, resulted from induction of Bad translocation to mitochondria, cytochrome-c release from mitochondria to cytosol, activation of caspase-3, 8, 9, and PARP cleavage. These results suggest that CHE may be potential therapeutic approach in the clinical management of stomach adenocarcinoma.